Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414315055> ?p ?o ?g. }
- W2414315055 abstract "Abstract A. baumannii infections are becoming more and more serious health issues with rapid emerging of multidrug and extremely drug resistant strains, and therefore, there is an urgent need for the development of nonantibiotic-based intervention strategies. This study aimed at identifying whether an outer membrane protein with molecular weight of about 22 kDa (Omp22) holds the potentials to be an efficient vaccine candidate and combat A. baumannii infection. Omp22 which has a molecule length of 217 amino acids kept more than 95% conservation in totally 851 reported A. baumannii strains. Recombinant Omp22 efficiently elicited high titers of specific IgG in mice. Both active and passive immunizations of Omp22 increased the survival rates of mice, suppressed the bacterial burdens in the organs and peripheral blood, and reduced the levels of serum inflammatory cytokines and chemokines. Opsonophagocytosis assays showed in vitro that Omp22 antiserum had highly efficient bactericidal activities on clonally distinct clinical A. baumannii isolates, which were partly complements-dependent and opsonophagocytic killing effects. Additionally, administration with as high as 500 μg of Omp22 didn’t cause obvious pathological changes in mice. In conclusion, Omp22 is a novel conserved and probably safe antigen for developing effective vaccines or antisera to control A. baumannii infections." @default.
- W2414315055 created "2016-06-24" @default.
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- W2414315055 date "2016-02-08" @default.
- W2414315055 modified "2023-10-18" @default.
- W2414315055 title "Immunization with a 22-kDa outer membrane protein elicits protective immunity to multidrug-resistant Acinetobacter baumannii" @default.
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- W2414315055 cites W1960496405 @default.
- W2414315055 cites W1967253673 @default.
- W2414315055 cites W1968114019 @default.
- W2414315055 cites W1974348924 @default.
- W2414315055 cites W1976641243 @default.
- W2414315055 cites W1987534021 @default.
- W2414315055 cites W1990697265 @default.
- W2414315055 cites W1991633654 @default.
- W2414315055 cites W1991883604 @default.
- W2414315055 cites W1995958191 @default.
- W2414315055 cites W1998133815 @default.
- W2414315055 cites W2007100259 @default.
- W2414315055 cites W2009373774 @default.
- W2414315055 cites W2014192657 @default.
- W2414315055 cites W2015313456 @default.
- W2414315055 cites W2015642465 @default.
- W2414315055 cites W2020173969 @default.
- W2414315055 cites W2023178925 @default.
- W2414315055 cites W2025431751 @default.
- W2414315055 cites W2025653817 @default.
- W2414315055 cites W2031445899 @default.
- W2414315055 cites W2034636924 @default.
- W2414315055 cites W2035433014 @default.
- W2414315055 cites W2052130550 @default.
- W2414315055 cites W2052303540 @default.
- W2414315055 cites W2057929627 @default.
- W2414315055 cites W2060809301 @default.
- W2414315055 cites W2061236919 @default.
- W2414315055 cites W2063730198 @default.
- W2414315055 cites W2074096962 @default.
- W2414315055 cites W2074965142 @default.
- W2414315055 cites W2075286202 @default.
- W2414315055 cites W2083206138 @default.
- W2414315055 cites W2083657436 @default.
- W2414315055 cites W2083889810 @default.
- W2414315055 cites W2084969271 @default.
- W2414315055 cites W2090084793 @default.
- W2414315055 cites W2101273146 @default.
- W2414315055 cites W2102186420 @default.
- W2414315055 cites W2110256580 @default.
- W2414315055 cites W2112355201 @default.
- W2414315055 cites W2113375673 @default.
- W2414315055 cites W2114686855 @default.
- W2414315055 cites W2115629722 @default.
- W2414315055 cites W2120654979 @default.
- W2414315055 cites W2131571136 @default.
- W2414315055 cites W2132620230 @default.
- W2414315055 cites W2136700350 @default.
- W2414315055 cites W2140372424 @default.
- W2414315055 cites W2140381975 @default.
- W2414315055 cites W2140750141 @default.
- W2414315055 cites W2141551975 @default.
- W2414315055 cites W2142140480 @default.
- W2414315055 cites W2142343447 @default.
- W2414315055 cites W2143988742 @default.
- W2414315055 cites W2152301430 @default.
- W2414315055 cites W2154021749 @default.
- W2414315055 cites W2159435953 @default.
- W2414315055 cites W2166663556 @default.
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- W2414315055 doi "https://doi.org/10.1038/srep20724" @default.
- W2414315055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4745112" @default.
- W2414315055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26853590" @default.
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