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- W2414324612 abstract "Utilizing a marker perfusion technique, jejunal absorption rates of free glycine and glycylglycine were investigated in five healthy human volunteers and 3 patients with an intestinal lesion resembling sprue. The absorption rates of both free glycine and glycylglycine were markedly reduced in the sprue patients, the reduction being more severe for free glycine than for glycylglycine (15-fold decrease versus 4-fold). In each patient, the glycine absorption rate was significantly greater from a test solution containing 50 mM glycylglycine than from a test solution containing a similar amount of glycine in the free form (100 mM). In 2 additional sprue patients the jejunal absorption rates of glycylglycine and glycyl-L-leucine were compared. There was no significant difference in the absorption rates of these two dipeptides, but both were markedly reduced. Our studies indicate that dipeptide is superior to free amino acid as a substrate for amino acid absorption even when the membrane transport is markedly reduced. Furthermore, the reduction in transport involves equally both a dipeptide with a poor potential (glycylglycine), as well as one with an excellent potential (glycylleucine) for hydrolysis by mucosal enzymes." @default.
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- W2414324612 date "1974-10-01" @default.
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- W2414324612 title "Comparison of Free Amino Acid and Dipeptide Absorption in the Jejunum of Sprue Patients" @default.
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- W2414324612 doi "https://doi.org/10.1016/s0016-5085(19)32783-0" @default.
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