FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414338248> ?p ?o ?g. }

• W2414338248 endingPage "224" @default.
• W2414338248 startingPage "209" @default.
• W2414338248 abstract "Triplex DNA has attracted considerable interest recently because of its possible biological functions in vivo and its wide variety of potential applications, such as regulation of gene expression, site-specific cleavage of duplex DNA, mapping of genomic DNA, and gene-targeted mutagenesis (1–3). A triplex is usually formed through the sequence-specific interaction of a single-stranded homopyrimidine or homopurine triplex-forming oligonucleotide (TFO) with the major groove of the homopurine-homopyrimidine stretch in duplex DNA (1–5). In the pyrimidine motif triplex, a homopyrimidine TFO binds parallel to the homopurine strand of the target duplex by Hoogsteen hydrogen bonding to form T●A:T and C+●G:C triplets (● and : represent Hoogsteen hydrogen bonding and Watson Crick base pairing, respectively). (1–5). Because the cytosine bases in a homopyrimidine TFO are to be protonated to bind with the guanine bases of the G:C duplex, the formation of the pyrimidine motif triplex needs an acidic pH condition, and is thus unstable at physiological pH (6–8). On the other hand, in the purine motif triplex, a homopurine TFO binds antiparallel to the homopurine strand of the target duplex by reverse Hoogsteen hydrogen bonding to form A●A:T (or T●A:T) and G●G:C triplets (1–5). Although the purine motif triplex is pH-independent, triplexes involving guanine-rich TFOs are inhibited by physiological concentrations of certain monovalent cations (M+), especially K+ (9,10)" @default.
• W2414338248 created "2016-06-24" @default.
• W2414338248 creator A5006151751 @default.
• W2414338248 creator A5024587258 @default.
• W2414338248 date "2003-11-14" @default.
• W2414338248 modified "2023-09-25" @default.
• W2414338248 title "Promotion of Duplex and Triplex DNA Formation by Polycation Comb-Type Copolymers" @default.
• W2414338248 cites W1487526850 @default.
• W2414338248 cites W1970284439 @default.
• W2414338248 cites W1978274422 @default.
• W2414338248 cites W1980572462 @default.
• W2414338248 cites W1982974867 @default.
• W2414338248 cites W1983157047 @default.
• W2414338248 cites W1985096669 @default.
• W2414338248 cites W1986064937 @default.
• W2414338248 cites W1988102395 @default.
• W2414338248 cites W1999222678 @default.
• W2414338248 cites W2015014732 @default.
• W2414338248 cites W2017157816 @default.
• W2414338248 cites W2020357919 @default.
• W2414338248 cites W2020586396 @default.
• W2414338248 cites W2024236380 @default.
• W2414338248 cites W2028094132 @default.
• W2414338248 cites W2035164099 @default.
• W2414338248 cites W2042209155 @default.
• W2414338248 cites W2050956642 @default.
• W2414338248 cites W2052333294 @default.
• W2414338248 cites W2055791011 @default.
• W2414338248 cites W2075053677 @default.
• W2414338248 cites W2076746045 @default.
• W2414338248 cites W2083771897 @default.
• W2414338248 cites W2086598566 @default.
• W2414338248 cites W2086779091 @default.
• W2414338248 cites W2088307552 @default.
• W2414338248 cites W2091406831 @default.
• W2414338248 cites W2091700323 @default.
• W2414338248 cites W2107142375 @default.
• W2414338248 cites W2111386319 @default.
• W2414338248 cites W2122117524 @default.
• W2414338248 cites W2123017921 @default.
• W2414338248 cites W2137825587 @default.
• W2414338248 cites W2151668141 @default.
• W2414338248 cites W2155591582 @default.
• W2414338248 cites W2156163511 @default.
• W2414338248 cites W2165373608 @default.
• W2414338248 cites W2167796192 @default.
• W2414338248 cites W2465928066 @default.
• W2414338248 cites W2949860727 @default.
• W2414338248 doi "https://doi.org/10.1385/1-59259-139-6:209" @default.
• W2414338248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21318757" @default.
• W2414338248 hasPublicationYear "2003" @default.
• W2414338248 type Work @default.
• W2414338248 sameAs 2414338248 @default.
• W2414338248 citedByCount "1" @default.
• W2414338248 countsByYear W24143382482012 @default.
• W2414338248 crossrefType "book-chapter" @default.
• W2414338248 hasAuthorship W2414338248A5006151751 @default.
• W2414338248 hasAuthorship W2414338248A5024587258 @default.
• W2414338248 hasConcept C104317684 @default.
• W2414338248 hasConcept C10919887 @default.
• W2414338248 hasConcept C115260700 @default.
• W2414338248 hasConcept C121332964 @default.
• W2414338248 hasConcept C129312508 @default.
• W2414338248 hasConcept C142089489 @default.
• W2414338248 hasConcept C185581394 @default.
• W2414338248 hasConcept C185592680 @default.
• W2414338248 hasConcept C2776023528 @default.
• W2414338248 hasConcept C2776858809 @default.
• W2414338248 hasConcept C2778301229 @default.
• W2414338248 hasConcept C2779321679 @default.
• W2414338248 hasConcept C512185932 @default.
• W2414338248 hasConcept C552990157 @default.
• W2414338248 hasConcept C55493867 @default.
• W2414338248 hasConcept C62520636 @default.
• W2414338248 hasConcept C71240020 @default.
• W2414338248 hasConcept C99611785 @default.
• W2414338248 hasConceptScore W2414338248C104317684 @default.
• W2414338248 hasConceptScore W2414338248C10919887 @default.
• W2414338248 hasConceptScore W2414338248C115260700 @default.
• W2414338248 hasConceptScore W2414338248C121332964 @default.
• W2414338248 hasConceptScore W2414338248C129312508 @default.
• W2414338248 hasConceptScore W2414338248C142089489 @default.
• W2414338248 hasConceptScore W2414338248C185581394 @default.
• W2414338248 hasConceptScore W2414338248C185592680 @default.
• W2414338248 hasConceptScore W2414338248C2776023528 @default.
• W2414338248 hasConceptScore W2414338248C2776858809 @default.
• W2414338248 hasConceptScore W2414338248C2778301229 @default.
• W2414338248 hasConceptScore W2414338248C2779321679 @default.
• W2414338248 hasConceptScore W2414338248C512185932 @default.
• W2414338248 hasConceptScore W2414338248C552990157 @default.
• W2414338248 hasConceptScore W2414338248C55493867 @default.
• W2414338248 hasConceptScore W2414338248C62520636 @default.
• W2414338248 hasConceptScore W2414338248C71240020 @default.
• W2414338248 hasConceptScore W2414338248C99611785 @default.
• W2414338248 hasLocation W24143382481 @default.
• W2414338248 hasLocation W24143382482 @default.
• W2414338248 hasOpenAccess W2414338248 @default.
• W2414338248 hasPrimaryLocation W24143382481 @default.

• next