Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414373211> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2414373211 abstract "The Hodgkin cell line U-HO1 was established from a malignant pleural effusion of a 23-yr-old male patient during the end stage of refractory nodular sclerosing classical Hodgkin lymphoma (cHL). Since its establishment in 2005, U-HO1 has maintained stable characteristics in vitro and has a doubling time of about 4 days under standard culture conditions. U-HO1 forms typical Reed/Sternberg cells in suspension, is EBV negative, lacks HLA-ABC- but expresses HLA-D- proteins/CD74 and surface exposes CD15 together with CD30 in the absence of CD19 and CD20. Karyotype analysis of U-HO1 revealed a hyperdiploid karyotype with multiple clonal aberrations. Most significant is an elongated chromosome 2, der(2)t(2;10)(q35;q16.1)add(2)(p13). CGH analysis revealed the following imbalances: ish cgh dim(1)(p13p31)(p12q21), enh(2)(p13p23), dim(4)(q31.3qter), enh(6)(q22q27), enh(12), enh(18),enh(20)(q13.1pter). FISH analysis showed about six-fold amplification of REL and BCL-11A, thus, U-HO1 is prototypical for cHL in every aspect tested so far. Compared to other HL cell lines, U-HO1 proved far less genetically aberrant suggesting that U-HO1's imbalances suffice to cause the full-blown phenotype of primary refractory cHL." @default.
- W2414373211 created "2016-06-24" @default.
- W2414373211 creator A5021170936 @default.
- W2414373211 creator A5023221138 @default.
- W2414373211 creator A5037724352 @default.
- W2414373211 creator A5059795103 @default.
- W2414373211 date "2008-09-28" @default.
- W2414373211 modified "2023-10-16" @default.
- W2414373211 title "U-HO1" @default.
- W2414373211 cites W2067562227 @default.
- W2414373211 cites W2095077052 @default.
- W2414373211 cites W2134620914 @default.
- W2414373211 cites W2526460909 @default.
- W2414373211 cites W89210232 @default.
- W2414373211 doi "https://doi.org/10.1007/s00292-008-1055-6" @default.
- W2414373211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18820924" @default.
- W2414373211 hasPublicationYear "2008" @default.
- W2414373211 type Work @default.
- W2414373211 sameAs 2414373211 @default.
- W2414373211 citedByCount "0" @default.
- W2414373211 crossrefType "journal-article" @default.
- W2414373211 hasAuthorship W2414373211A5021170936 @default.
- W2414373211 hasAuthorship W2414373211A5023221138 @default.
- W2414373211 hasAuthorship W2414373211A5037724352 @default.
- W2414373211 hasAuthorship W2414373211A5059795103 @default.
- W2414373211 hasBestOaLocation W24143732111 @default.
- W2414373211 hasConcept C10205521 @default.
- W2414373211 hasConcept C104317684 @default.
- W2414373211 hasConcept C147483822 @default.
- W2414373211 hasConcept C153911025 @default.
- W2414373211 hasConcept C18031839 @default.
- W2414373211 hasConcept C203014093 @default.
- W2414373211 hasConcept C2776804306 @default.
- W2414373211 hasConcept C2779067128 @default.
- W2414373211 hasConcept C2779338263 @default.
- W2414373211 hasConcept C28328180 @default.
- W2414373211 hasConcept C30481170 @default.
- W2414373211 hasConcept C53226629 @default.
- W2414373211 hasConcept C54355233 @default.
- W2414373211 hasConcept C86803240 @default.
- W2414373211 hasConceptScore W2414373211C10205521 @default.
- W2414373211 hasConceptScore W2414373211C104317684 @default.
- W2414373211 hasConceptScore W2414373211C147483822 @default.
- W2414373211 hasConceptScore W2414373211C153911025 @default.
- W2414373211 hasConceptScore W2414373211C18031839 @default.
- W2414373211 hasConceptScore W2414373211C203014093 @default.
- W2414373211 hasConceptScore W2414373211C2776804306 @default.
- W2414373211 hasConceptScore W2414373211C2779067128 @default.
- W2414373211 hasConceptScore W2414373211C2779338263 @default.
- W2414373211 hasConceptScore W2414373211C28328180 @default.
- W2414373211 hasConceptScore W2414373211C30481170 @default.
- W2414373211 hasConceptScore W2414373211C53226629 @default.
- W2414373211 hasConceptScore W2414373211C54355233 @default.
- W2414373211 hasConceptScore W2414373211C86803240 @default.
- W2414373211 hasLocation W24143732111 @default.
- W2414373211 hasLocation W24143732112 @default.
- W2414373211 hasOpenAccess W2414373211 @default.
- W2414373211 hasPrimaryLocation W24143732111 @default.
- W2414373211 hasRelatedWork W1963610945 @default.
- W2414373211 hasRelatedWork W1964634382 @default.
- W2414373211 hasRelatedWork W1970446973 @default.
- W2414373211 hasRelatedWork W2003707250 @default.
- W2414373211 hasRelatedWork W2036524875 @default.
- W2414373211 hasRelatedWork W2057037204 @default.
- W2414373211 hasRelatedWork W2273436800 @default.
- W2414373211 hasRelatedWork W2333753135 @default.
- W2414373211 hasRelatedWork W2386103056 @default.
- W2414373211 hasRelatedWork W2411713619 @default.
- W2414373211 isParatext "false" @default.
- W2414373211 isRetracted "false" @default.
- W2414373211 magId "2414373211" @default.
- W2414373211 workType "article" @default.