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- W2414373280 endingPage "1937" @default.
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- W2414373280 abstract "Consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT) is the standard of care for transplantation-eligible patients with multiple myeloma, based on randomized trials showing improved progression-free survival with autologous transplantation after combination chemotherapy induction. These trials were performed before novel agents were introduced; subsequently, combinations of immunomodulatory drugs and proteasome inhibitors as induction therapy have significantly improved rates and depth of response. Ongoing randomized trials are testing whether conventional autologous transplantation continues to improve responses after novel agent induction. Although these results are awaited, it is important to review strategies for improving outcomes after ASCT. Conditioning before ASCT with higher doses of melphalan and combinations of melphalan with other agents, including radiopharmaceuticals, has been explored. Tandem ASCT, consolidation, and maintenance therapy after ASCT have been investigated in phase III trials. Experimental cellular therapies using ex vivo–primed dendritic cells, ex vivo–expanded autologous lymphocytes, Killer Immunoglobulin Receptor (KIR)-mismatched allogeneic natural killer cells, and genetically modified T cells to augment ASCT are also in phase I trials. This review summarizes these strategies and highlights the importance of exploring strategies to augment ASCT, even in the era of novel agent induction." @default.
- W2414373280 created "2016-06-24" @default.
- W2414373280 creator A5038580329 @default.
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- W2414373280 creator A5068293508 @default.
- W2414373280 creator A5072918409 @default.
- W2414373280 creator A5087107462 @default.
- W2414373280 date "2016-11-01" @default.
- W2414373280 modified "2023-09-26" @default.
- W2414373280 title "Augmenting Autologous Stem Cell Transplantation to Improve Outcomes in Myeloma" @default.
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