Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414392594> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2414392594 endingPage "46" @default.
- W2414392594 startingPage "37" @default.
- W2414392594 abstract "Cerebrovascular amyloidosis belongs to the pathological hallmarks of Alzheimer's disease brains. Although definite proof is still lacking, it is very well possible that the amyloid and its associated proteins are produced locally in the brain. In this paper we describe the development of a model system of cultured human brain pericytes to study the mechanisms of microvascular amyloid formation in vitro. These cultured cells may serve to study several aspects of cerebrovascular amyloidosis, which include the production of the amyloid precursor protein and of amyloid beta-protein-associated proteins as well as cytotoxic effects of amyloid beta-protein on perivascular cells. We demonstrated that pericytes produce and metabolize the amyloid precursor protein, and that they produce amyloid beta-protein-associated proteins, such as heparan sulfate proteoglycans, apolipoprotein E, and complement factor C1q. They are also prone to cellular degeneration after treatment with amyloid beta-protein, which is accompanied by increased expression of a number of amyloid beta-protein-associated proteins. This may be an important mechanism to explain the cell death observed in vivo. Our data indicate that this cell culture model of human brain pericytes provides a useful and pathophysiologically relevant tool to study cerebrovascular amyloidosis." @default.
- W2414392594 created "2016-06-24" @default.
- W2414392594 creator A5008603484 @default.
- W2414392594 creator A5014341607 @default.
- W2414392594 creator A5033567523 @default.
- W2414392594 creator A5057231045 @default.
- W2414392594 date "1999-02-01" @default.
- W2414392594 modified "2023-09-28" @default.
- W2414392594 title "Human brain pericytes as a model system to study the pathogenesis of cerebrovascular amyloidosis in Alzheimer's disease." @default.
- W2414392594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10099838" @default.
- W2414392594 hasPublicationYear "1999" @default.
- W2414392594 type Work @default.
- W2414392594 sameAs 2414392594 @default.
- W2414392594 citedByCount "6" @default.
- W2414392594 countsByYear W24143925942013 @default.
- W2414392594 countsByYear W24143925942019 @default.
- W2414392594 countsByYear W24143925942023 @default.
- W2414392594 crossrefType "journal-article" @default.
- W2414392594 hasAuthorship W2414392594A5008603484 @default.
- W2414392594 hasAuthorship W2414392594A5014341607 @default.
- W2414392594 hasAuthorship W2414392594A5033567523 @default.
- W2414392594 hasAuthorship W2414392594A5057231045 @default.
- W2414392594 hasConcept C142724271 @default.
- W2414392594 hasConcept C151484617 @default.
- W2414392594 hasConcept C177907266 @default.
- W2414392594 hasConcept C180081513 @default.
- W2414392594 hasConcept C185592680 @default.
- W2414392594 hasConcept C203014093 @default.
- W2414392594 hasConcept C2777633098 @default.
- W2414392594 hasConcept C2779134260 @default.
- W2414392594 hasConcept C2779951007 @default.
- W2414392594 hasConcept C2780942790 @default.
- W2414392594 hasConcept C31705614 @default.
- W2414392594 hasConcept C502032728 @default.
- W2414392594 hasConcept C57089818 @default.
- W2414392594 hasConcept C68026918 @default.
- W2414392594 hasConcept C71924100 @default.
- W2414392594 hasConcept C86803240 @default.
- W2414392594 hasConcept C95444343 @default.
- W2414392594 hasConceptScore W2414392594C142724271 @default.
- W2414392594 hasConceptScore W2414392594C151484617 @default.
- W2414392594 hasConceptScore W2414392594C177907266 @default.
- W2414392594 hasConceptScore W2414392594C180081513 @default.
- W2414392594 hasConceptScore W2414392594C185592680 @default.
- W2414392594 hasConceptScore W2414392594C203014093 @default.
- W2414392594 hasConceptScore W2414392594C2777633098 @default.
- W2414392594 hasConceptScore W2414392594C2779134260 @default.
- W2414392594 hasConceptScore W2414392594C2779951007 @default.
- W2414392594 hasConceptScore W2414392594C2780942790 @default.
- W2414392594 hasConceptScore W2414392594C31705614 @default.
- W2414392594 hasConceptScore W2414392594C502032728 @default.
- W2414392594 hasConceptScore W2414392594C57089818 @default.
- W2414392594 hasConceptScore W2414392594C68026918 @default.
- W2414392594 hasConceptScore W2414392594C71924100 @default.
- W2414392594 hasConceptScore W2414392594C86803240 @default.
- W2414392594 hasConceptScore W2414392594C95444343 @default.
- W2414392594 hasIssue "1" @default.
- W2414392594 hasLocation W24143925941 @default.
- W2414392594 hasOpenAccess W2414392594 @default.
- W2414392594 hasPrimaryLocation W24143925941 @default.
- W2414392594 hasRelatedWork W101759737 @default.
- W2414392594 hasRelatedWork W2026675274 @default.
- W2414392594 hasRelatedWork W2078960123 @default.
- W2414392594 hasRelatedWork W2097222948 @default.
- W2414392594 hasRelatedWork W2099518529 @default.
- W2414392594 hasRelatedWork W2310238648 @default.
- W2414392594 hasRelatedWork W2414392594 @default.
- W2414392594 hasRelatedWork W2470055077 @default.
- W2414392594 hasRelatedWork W90610448 @default.
- W2414392594 hasRelatedWork W166558667 @default.
- W2414392594 hasVolume "45" @default.
- W2414392594 isParatext "false" @default.
- W2414392594 isRetracted "false" @default.
- W2414392594 magId "2414392594" @default.
- W2414392594 workType "article" @default.