Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414398891> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2414398891 endingPage "56" @default.
- W2414398891 startingPage "3947" @default.
- W2414398891 abstract "Activated lymphocytes have the ability to undergo non-directional cell movement known as random migration, although the biological role for this remains unclear. Herein, we investigated how random migration affects cytotoxicity of activated lymphocytes using time-lapse imaging analysis. The kinetics of random migration paralleled cytotoxicity in activated lymphocytes. Sphingosine-1-phosphate (S1P) and its receptor-1 (S1PR1) play an important role in lymphocyte migration. Phosphorylated FTY720 (FTYP), a structural analog of S1P, significantly inhibited random migration and cytotoxicity of activated CD3(+)NKG2D(+)CD8(+) T-lymphocytes but not CD3(-)NKG2D(+)CD56(+) natural killer (NK) cells. In a mouse xenograft model, FTYP-treated activated lymphocytes exhibited lower cytotoxicity and less tumor infiltration for activated CD3(+)NKG2D(+) T-lymphocytes but not CD3(-)NKG2D(+) NK cells. These results suggest that random migration contributes to the cytotoxicity of activated CD8(+) T-cells but not of NK cells." @default.
- W2414398891 created "2016-06-24" @default.
- W2414398891 creator A5000528022 @default.
- W2414398891 creator A5024686279 @default.
- W2414398891 creator A5039376946 @default.
- W2414398891 creator A5077613670 @default.
- W2414398891 creator A5078418006 @default.
- W2414398891 creator A5089569040 @default.
- W2414398891 creator A5091882168 @default.
- W2414398891 date "2014-08-01" @default.
- W2414398891 modified "2023-09-23" @default.
- W2414398891 title "Random migration contributes to cytotoxicity of activated CD8+ T-lymphocytes but not NK cells." @default.
- W2414398891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25075016" @default.
- W2414398891 hasPublicationYear "2014" @default.
- W2414398891 type Work @default.
- W2414398891 sameAs 2414398891 @default.
- W2414398891 citedByCount "4" @default.
- W2414398891 countsByYear W24143988912016 @default.
- W2414398891 countsByYear W24143988912019 @default.
- W2414398891 countsByYear W24143988912020 @default.
- W2414398891 countsByYear W24143988912022 @default.
- W2414398891 crossrefType "journal-article" @default.
- W2414398891 hasAuthorship W2414398891A5000528022 @default.
- W2414398891 hasAuthorship W2414398891A5024686279 @default.
- W2414398891 hasAuthorship W2414398891A5039376946 @default.
- W2414398891 hasAuthorship W2414398891A5077613670 @default.
- W2414398891 hasAuthorship W2414398891A5078418006 @default.
- W2414398891 hasAuthorship W2414398891A5089569040 @default.
- W2414398891 hasAuthorship W2414398891A5091882168 @default.
- W2414398891 hasConcept C109316439 @default.
- W2414398891 hasConcept C114684123 @default.
- W2414398891 hasConcept C153911025 @default.
- W2414398891 hasConcept C154317977 @default.
- W2414398891 hasConcept C167672396 @default.
- W2414398891 hasConcept C185592680 @default.
- W2414398891 hasConcept C202751555 @default.
- W2414398891 hasConcept C203014093 @default.
- W2414398891 hasConcept C2777761686 @default.
- W2414398891 hasConcept C2778102761 @default.
- W2414398891 hasConcept C2778867473 @default.
- W2414398891 hasConcept C502942594 @default.
- W2414398891 hasConcept C55493867 @default.
- W2414398891 hasConcept C86803240 @default.
- W2414398891 hasConcept C8891405 @default.
- W2414398891 hasConcept C95444343 @default.
- W2414398891 hasConceptScore W2414398891C109316439 @default.
- W2414398891 hasConceptScore W2414398891C114684123 @default.
- W2414398891 hasConceptScore W2414398891C153911025 @default.
- W2414398891 hasConceptScore W2414398891C154317977 @default.
- W2414398891 hasConceptScore W2414398891C167672396 @default.
- W2414398891 hasConceptScore W2414398891C185592680 @default.
- W2414398891 hasConceptScore W2414398891C202751555 @default.
- W2414398891 hasConceptScore W2414398891C203014093 @default.
- W2414398891 hasConceptScore W2414398891C2777761686 @default.
- W2414398891 hasConceptScore W2414398891C2778102761 @default.
- W2414398891 hasConceptScore W2414398891C2778867473 @default.
- W2414398891 hasConceptScore W2414398891C502942594 @default.
- W2414398891 hasConceptScore W2414398891C55493867 @default.
- W2414398891 hasConceptScore W2414398891C86803240 @default.
- W2414398891 hasConceptScore W2414398891C8891405 @default.
- W2414398891 hasConceptScore W2414398891C95444343 @default.
- W2414398891 hasIssue "8" @default.
- W2414398891 hasLocation W24143988911 @default.
- W2414398891 hasOpenAccess W2414398891 @default.
- W2414398891 hasPrimaryLocation W24143988911 @default.
- W2414398891 hasRelatedWork W1969995434 @default.
- W2414398891 hasRelatedWork W2018916009 @default.
- W2414398891 hasRelatedWork W2034160312 @default.
- W2414398891 hasRelatedWork W2050452952 @default.
- W2414398891 hasRelatedWork W2089407853 @default.
- W2414398891 hasRelatedWork W2133020152 @default.
- W2414398891 hasRelatedWork W2187132487 @default.
- W2414398891 hasRelatedWork W2414398891 @default.
- W2414398891 hasRelatedWork W2563867961 @default.
- W2414398891 hasRelatedWork W71761651 @default.
- W2414398891 hasVolume "34" @default.
- W2414398891 isParatext "false" @default.
- W2414398891 isRetracted "false" @default.
- W2414398891 magId "2414398891" @default.
- W2414398891 workType "article" @default.