FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414401286> ?p ?o ?g. }

• W2414401286 endingPage "e0144052" @default.
• W2414401286 startingPage "e0144052" @default.
• W2414401286 abstract "Network-based approaches are powerful and beneficial tools to study complex systems in their entirety, elucidating the essential factors that turn the multitude of individual elements into a functional system. In this study we used critical network topology descriptors and guilt-by-association rule to explore and understand the significant molecular players, drug targets and underlying biological mechanisms of Alzheimer’s disease. Analyzing two post-mortem brain gene microarrays (GSE4757 and GSE28146) with Pathway Studio software package we constructed and analyzed a set of protein-protein interaction, as well as miRNA-target networks. In a 4-step procedure the expression datasets were normalized using Robust Multi-array Average approach, while the modulation of gene expression by the disease was statistically evaluated by the empirical Bayes method from the limma Bioconductor package. Representative set of 214 seed-genes (p<0.01) common for the three brain sections of the two microarrays was thus created. The Pathway Studio analysis of the networks built identified 15 new potential AD-related genes and 17 novel AD-involved microRNAs. Using KEGG pathways relevant in Alzheimer’s disease we built an integrated mechanistic network from the interactions between the overlapping genes in these pathways. Routes of possible disease initiation process were thus revealed through the CD4, DCN, and IL8 extracellular ligands. DAVID and IPA enrichment analysis uncovered a number of deregulated biological processes and pathways including neuron projection/differentiation, aging, oxidative stress, chemokine/ neurotrophin signaling, long-term potentiation and others. The findings in this study offer information of interest for subsequent experimental studies." @default.
• W2414401286 created "2016-06-24" @default.
• W2414401286 creator A5017568569 @default.
• W2414401286 creator A5044573961 @default.
• W2414401286 date "2016-01-19" @default.
• W2414401286 modified "2023-10-06" @default.
• W2414401286 title "Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer’s Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease" @default.
• W2414401286 cites W1272661702 @default.
• W2414401286 cites W1486817521 @default.
• W2414401286 cites W1494364449 @default.
• W2414401286 cites W1502348633 @default.
• W2414401286 cites W1516122098 @default.
• W2414401286 cites W1534001036 @default.
• W2414401286 cites W1536472139 @default.
• W2414401286 cites W1543848190 @default.
• W2414401286 cites W1564001101 @default.
• W2414401286 cites W1595078459 @default.
• W2414401286 cites W1605153887 @default.
• W2414401286 cites W1653912017 @default.
• W2414401286 cites W1852059769 @default.
• W2414401286 cites W1966016176 @default.
• W2414401286 cites W1975167087 @default.
• W2414401286 cites W1979987334 @default.
• W2414401286 cites W1982959887 @default.
• W2414401286 cites W1987933993 @default.
• W2414401286 cites W1990876270 @default.
• W2414401286 cites W1991334828 @default.
• W2414401286 cites W1996245560 @default.
• W2414401286 cites W1997653708 @default.
• W2414401286 cites W1997838879 @default.
• W2414401286 cites W2002081498 @default.
• W2414401286 cites W2003597523 @default.
• W2414401286 cites W2005799786 @default.
• W2414401286 cites W2005889734 @default.
• W2414401286 cites W2007002248 @default.
• W2414401286 cites W2007056331 @default.
• W2414401286 cites W2010484888 @default.
• W2414401286 cites W2014346868 @default.
• W2414401286 cites W2014882928 @default.
• W2414401286 cites W2015497016 @default.
• W2414401286 cites W2019534026 @default.
• W2414401286 cites W2023825688 @default.
• W2414401286 cites W2024492106 @default.
• W2414401286 cites W2028827022 @default.
• W2414401286 cites W2030575711 @default.
• W2414401286 cites W2033624038 @default.
• W2414401286 cites W2034201162 @default.
• W2414401286 cites W2035609698 @default.
• W2414401286 cites W2037335353 @default.
• W2414401286 cites W2038182267 @default.
• W2414401286 cites W2041029999 @default.
• W2414401286 cites W2046480957 @default.
• W2414401286 cites W2056126207 @default.
• W2414401286 cites W2066124024 @default.
• W2414401286 cites W2067814945 @default.
• W2414401286 cites W2071420631 @default.
• W2414401286 cites W2072484559 @default.
• W2414401286 cites W2077817699 @default.
• W2414401286 cites W2081098333 @default.
• W2414401286 cites W2081412929 @default.
• W2414401286 cites W2085245632 @default.
• W2414401286 cites W2087243986 @default.
• W2414401286 cites W2091026347 @default.
• W2414401286 cites W2091934374 @default.
• W2414401286 cites W2097362385 @default.
• W2414401286 cites W2110280725 @default.
• W2414401286 cites W2110370838 @default.
• W2414401286 cites W2113716558 @default.
• W2414401286 cites W2116485041 @default.
• W2414401286 cites W2116784956 @default.
• W2414401286 cites W2120522615 @default.
• W2414401286 cites W2121926054 @default.
• W2414401286 cites W2122164926 @default.
• W2414401286 cites W2122683221 @default.
• W2414401286 cites W2122918415 @default.
• W2414401286 cites W2129495914 @default.
• W2414401286 cites W2130087890 @default.
• W2414401286 cites W2133465414 @default.
• W2414401286 cites W2135957529 @default.
• W2414401286 cites W2139726138 @default.
• W2414401286 cites W2141262291 @default.
• W2414401286 cites W2145395978 @default.
• W2414401286 cites W2146141276 @default.
• W2414401286 cites W2149193660 @default.
• W2414401286 cites W2151583377 @default.
• W2414401286 cites W2152381240 @default.
• W2414401286 cites W2157405068 @default.
• W2414401286 cites W2158217645 @default.
• W2414401286 cites W2159482845 @default.
• W2414401286 cites W2160697532 @default.
• W2414401286 cites W2160855812 @default.
• W2414401286 cites W2163608581 @default.
• W2414401286 cites W2165280164 @default.
• W2414401286 cites W2168391904 @default.
• W2414401286 cites W2169152986 @default.
• W2414401286 cites W2170989872 @default.
• W2414401286 cites W2171223421 @default.
• W2414401286 cites W2172020514 @default.

• next