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• W2414402983 abstract "Riyadh, Saudi Arabia. The same cohort had already been described in previous publications. At diagnosis anaemia, lymphopaenia and leukopaenia, low complement, positive Coomb’s test, prolonged coagulation time and positive antiphospholipid antibodies were frequently seen. At the last follow up anaemia, lymphopaenia and low complement were frequently present. Anaemia was the most common manifestation both at diagnosis and at last follow up. Differences with frequencies reported for other cohorts from other countries are at least partially due to what types of anaemia were included. The authors found different associations between the haematological abnormalities and other disease manifestations but it is unclear to what extent this is useful in guiding monitoring and treatment of SLE patients. Mild to moderate anaemia is very frequently present in patients with SLE and can contribute to other symptoms such as fatigue. In clinical practice, the anaemia is often multifactorial with causes including the active disease itself, direct and indirect effects of drugs and associated conditions. It is not always easy to diagnose the exact contribution of each of these factors and treat appropriately. In patients with chronic anaemia it can also be difficult to decide when to reinvestigate for contributing factors that can be treated. Psychiatric manifestations in patients with SLE are common including early in the course of the disease. They are associated with lower quality of life, increased functional disability, sleep disorders, increased unemployment rate and health service utilization. They also contribute to non-adherence to treatment. These manifestations are frequently undiagnosed and undertreated. This is partially due to uncertainty about its exact cause, i.e., whether they reflect active immune mechanisms and central nervous system pathology or the psychosocial impact of a chronic disease, and to Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs and systems. It is characterized by a relapsing and remitting course with flares of variable severity. It frequently affects young woman of childbearing age. The last decades have seen large advances in the treatment of SLE but it remains a disease associated with conside rable morbidity and important mortality. In this issue of the Acta Reumatologica Portuguesa three different articles on SLE are published. The article by Aleem et al. is a report on a retrospective cohort study looking at the frequency of haematological abnormalities and clinical haematological manifestations in patients with SLE both at diagnosis and after a mean follow up of 10 years and their association with other disease manifestations and organ involvement. The two other articles are reviews of the literature focusing on psychiatric manifestations in patients with SLE. Vargas and Vaz present a systematic literature review spanning 10 years of articles investigating methods of screening for probable psychiatric manifestations of SLE: cognitive dysfunction and mood and anxiety disorders. Braga and Campar review the published evidence for biological cau ses of depression in patients with SLE. Haematological abnormalities are among the most common abnormalities detected in the assessment of patients with SLE and are associated with significant clinical manifestations. Previous studies have sugges ted that the frequency of different disease manifestations in SLE can vary in different populations. The article of Aleem et al is a retrospective study of a cohort of more than 600 patients followed up in a University Centre in" @default.
• W2414402983 created "2016-06-24" @default.
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• W2414402983 date "2014-10-19" @default.
• W2414402983 modified "2023-09-28" @default.
• W2414402983 title "Systemic lupus erythematosus: frequency of haematological abnormalities and screening for and causes of psychiatric manifestations." @default.
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