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- W2414442095 abstract "Macrophages are crucial for proper sperm production by contributing to the milieu that supports the differentiation of spermatogonia, according to a new study in mice [1]. Macrophages are abundant in the testes, and are known to promote testosterone production by associating with Leydig cells. Tony DeFalco et al. found distinct populations of macrophages in the testes, one on the surface of seminiferous tubules. These macrophages tended to localize adjacent to cells inside the tubule that had been stained with a marker for undifferentiated and early-differentiating spermatogonia. The researchers performed experiments ablating macrophages in the testes, and found reductions in the number of differentiating spermatogonia, and a reduction in cell cycle activity. These effects did not seem to be mediated by the loss of Leydig cell-associated macrophages—for instance, testosterone levels were reduced only by about half, enough to sustain spermatogenesis. The researchers speculate that macrophages, independently or in conjunction with another cell type, promote the differentiation of spermatogonia. This effect seems to occur in part through two factors known to promote such differentiation—CSF1 (Colony Stimulating Factor 1) and retinoic acid. Macrophages seem to be a source of these molecules, the new data suggest. The findings help flesh out the characteristics of the niche supporting spermatogenesis, an environment that has been difficult to fully characterize, in part because it seems to lack a defined morphological location. Perhaps proximity to macrophages is a key component of this niche." @default.
- W2414442095 created "2016-06-24" @default.
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- W2414442095 date "2015-08-19" @default.
- W2414442095 modified "2023-09-25" @default.
- W2414442095 title "Macrophages Make the Man-in Mice" @default.
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- W2414442095 doi "https://doi.org/10.1095/biolreprod.115.134809" @default.
- W2414442095 hasPublicationYear "2015" @default.
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