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- W2414449179 startingPage "50" @default.
- W2414449179 abstract "Thrombolytic therapy has had a major impact on reducing mortality and preserving segmental ventricular function in patients with Q-wave infarcts who are treated early. Despite this substantial progress, a number of problems remain, most of which are related to the rate at which thrombolysis occurs and the risk of reocclusion of the infarct-related artery. Efforts need to be aimed at identifying and improving thrombolytic regimens that are capable of shortening the interval between the onset of ischemia and the achievement of reperfusion, as well as preventing reocclusion. Third-generation thrombolytic agents, including mutants of thrombolytic agents that are currently available, and different combinations of antiplatelet and thrombolytic regimens need to be tested for their abilities to reduce the time to thrombolysis and to delay or prevent reocclusion, without markedly increasing the risk of bleeding. Such adjunctive therapy might be provided by a variety of antiplatelet drugs, including combinations of thromboxane A(2) synthesis inhibitors and receptor antagonists with serotonin receptor antagonists; thrombin antagonists; possibly platelet-activating factor antagonists; or monoclonal antibodies to the platelet receptors responsible for platelet attachment, platelet aggregation, or both." @default.
- W2414449179 created "2016-06-24" @default.
- W2414449179 creator A5034394063 @default.
- W2414449179 creator A5045515686 @default.
- W2414449179 date "1991-01-01" @default.
- W2414449179 modified "2023-09-25" @default.
- W2414449179 title "Is thrombolysis alone the best therapy for acute myocardial infarction? Current status and emerging strategies." @default.
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