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• W2414458013 abstract "No AccessJournal of Urology1 May 1993Inhibitory Effect of Cromakalim in Human Detrusor Muscle is Mediated by Glibenclamide-Sensitive Potassium Channels Roberto Soares de Moura, Rodolfo Fernandes de Mello, and Sergio D’Aguinaga Roberto Soares de MouraRoberto Soares de Moura More articles by this author , Rodolfo Fernandes de MelloRodolfo Fernandes de Mello More articles by this author , and Sergio D’AguinagaSergio D’Aguinaga More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36341-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The effects of cromakalim, a potassium channel activating drug, and glibenclamide, a relatively selective antagonist of ATP-sensitive potassium channels, have been investigated on isolated detrusor muscle from human bladder. Specimens of human bladder were cut into strips and suspended in an organ bath filled with modified Tyrode solution for measurement of isometric contractile force. Concentration-response curves to acetylcholine were constructed before and after pretreatment with cromakalim and cromakalim plus glibenclamide. The concentration-response curves to acetylcholine were displaced to the right, and the maximal response to acetylcholine was significantly inhibited by cromakalim in a concentration-dependent manner. The inhibitory effect of cromakalim on acetylcholine-induced contraction was significantly reduced by glibenclamide. Following sustained contraction induced by 20mM. KCl, the cumulative addition of cromakalim to the organ bath produced a concentration-dependent relaxation. However, in strips precontracted with 60mM. KCl, the addition of cromakalim in concentrations as high as 10−5M. did not induce relaxation. The relaxation induced by cromakalim in strips precontracted with 20mM. KCl was significantly inhibited by glibenclamide. These results suggest that the inhibitory effect of cromakalim in human bladder involves activation of glibenclamide-sensitive potassium channels. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 149Issue 5 Part 1May 1993Page: 1174-1177 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.KeywordsbladdeacetylcholineglyburideMetricsAuthor Information Roberto Soares de Moura More articles by this author Rodolfo Fernandes de Mello More articles by this author Sergio D’Aguinaga More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2414458013 title "Inhibitory Effect of Cromakalim in Human Detrusor Muscle is Mediated by Glibenclamide-Sensitive Potassium Channels" @default.
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• W2414458013 doi "https://doi.org/10.1016/s0022-5347(17)36341-3" @default.
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