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- W2414461941 abstract "To investigate the expression of transforming growth factor-beta receptor II (TGF-beta R II) in periretinal membranes of proliferative vitreoretinopathy (PVR).Immunohistochemistry and in situ hybridization were used to detect the expression of TGF-beta R II protein and mRNA in sixteen proliferative membranes of thirteen PVR patients.Immunohistochemically staining showed that membranes labeled negative -, weak positive +, positive 2+ and strong positive staining 3+ were respectively noted one, one, three and four membranes in nine C2-C3 membranes. Total positive cell rate is 88.9%. Among seven D1-D3 membranes, one membrane was labeled -, three were + and another three membranes were labeled 2+. Total positive cell rate is 85.7%. Positive staining cells were of a type of epithelial-like cells which frequently found pigment in or around them. Relation between TGF-beta R II expression and membrane grades appeared no correlation (P > 0.05). Results of in situ hybridization were almost consistent with that of immunohistochemistry.Both TGF-beta R II protein and mRNA are highly expressed and up-regulated in PVR membranes by cytokine stimulation, moreover TGF-beta may play important role in the pathogenesis of PVR." @default.
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- W2414461941 date "2003-12-01" @default.
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- W2414461941 title "[Expression of TGF-beta receptor II in periretinal membranes of proliferative vitreoretinopathy]." @default.
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