Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414464590> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2414464590 endingPage "95" @default.
- W2414464590 startingPage "588" @default.
- W2414464590 abstract "The patch-clamp technique in cell-attached configuration was applied to investigate suberyldicholine-induced currents in Planorbarius corneus neurons. The single channels currents registered as inward ones at hyperpolarization of the patches were due to chloride ions efflux from the cell. Suberyldicholine (5 mumol/l) was added into the patch electrode. Usually there were more than one channel in the membrane fragment under the clamp control. The open and closed times, bursts and clusters' lengths were measured and histograms of single-channel parameters were obtained. Histograms were approximated by a sum of exponentials. Single exponentials were fitted to open times; to = 27 +/- 3 ms (n = 21). Histograms of closed times were fitted by three exponentials: tc1 = 9.5 +/- 1.0 ms (n = 21)--short gaps; tc2 = 171 +/- 33 ms (n = 19)--intermediate gaps: tc3 = 5.2 +/- 1.0 s (n = 21)--long gaps. The openings were grouped in bursts: tb2 = 203 +/- 23 ms (n = 10) and in clusters of bursts: tk3 = 1.5 +/- 0.5 s (n = 9). There were some evidences that the single burst was the result of opening, closing and reopening of just the same channel. A kinetic model with one open and three nonconducting states is plausible for single-channel data. Two long-lasting closed times may be associated with desensitization states of the receptor-channel complex. Estimates of the kinetic model parameters were obtained, that may be useful in the further study of a mode of action for cholinergic drugs in Planorbarius corneus neurons." @default.
- W2414464590 created "2016-06-24" @default.
- W2414464590 creator A5005949917 @default.
- W2414464590 creator A5015041038 @default.
- W2414464590 creator A5045908405 @default.
- W2414464590 date "1991-01-01" @default.
- W2414464590 modified "2023-10-18" @default.
- W2414464590 title "[Kinetics of work of ion channels operated by nicotinic cholinoreceptors in the membrane of mollusk neurons]." @default.
- W2414464590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1724060" @default.
- W2414464590 hasPublicationYear "1991" @default.
- W2414464590 type Work @default.
- W2414464590 sameAs 2414464590 @default.
- W2414464590 citedByCount "0" @default.
- W2414464590 crossrefType "journal-article" @default.
- W2414464590 hasAuthorship W2414464590A5005949917 @default.
- W2414464590 hasAuthorship W2414464590A5015041038 @default.
- W2414464590 hasAuthorship W2414464590A5045908405 @default.
- W2414464590 hasConcept C100837961 @default.
- W2414464590 hasConcept C121332964 @default.
- W2414464590 hasConcept C12554922 @default.
- W2414464590 hasConcept C135889238 @default.
- W2414464590 hasConcept C145148216 @default.
- W2414464590 hasConcept C147944092 @default.
- W2414464590 hasConcept C148898269 @default.
- W2414464590 hasConcept C170493617 @default.
- W2414464590 hasConcept C178790620 @default.
- W2414464590 hasConcept C181911157 @default.
- W2414464590 hasConcept C185592680 @default.
- W2414464590 hasConcept C50254741 @default.
- W2414464590 hasConcept C55493867 @default.
- W2414464590 hasConcept C74650414 @default.
- W2414464590 hasConcept C86803240 @default.
- W2414464590 hasConceptScore W2414464590C100837961 @default.
- W2414464590 hasConceptScore W2414464590C121332964 @default.
- W2414464590 hasConceptScore W2414464590C12554922 @default.
- W2414464590 hasConceptScore W2414464590C135889238 @default.
- W2414464590 hasConceptScore W2414464590C145148216 @default.
- W2414464590 hasConceptScore W2414464590C147944092 @default.
- W2414464590 hasConceptScore W2414464590C148898269 @default.
- W2414464590 hasConceptScore W2414464590C170493617 @default.
- W2414464590 hasConceptScore W2414464590C178790620 @default.
- W2414464590 hasConceptScore W2414464590C181911157 @default.
- W2414464590 hasConceptScore W2414464590C185592680 @default.
- W2414464590 hasConceptScore W2414464590C50254741 @default.
- W2414464590 hasConceptScore W2414464590C55493867 @default.
- W2414464590 hasConceptScore W2414464590C74650414 @default.
- W2414464590 hasConceptScore W2414464590C86803240 @default.
- W2414464590 hasIssue "5" @default.
- W2414464590 hasLocation W24144645901 @default.
- W2414464590 hasOpenAccess W2414464590 @default.
- W2414464590 hasPrimaryLocation W24144645901 @default.
- W2414464590 hasRelatedWork W1906538903 @default.
- W2414464590 hasRelatedWork W1980322257 @default.
- W2414464590 hasRelatedWork W2007209741 @default.
- W2414464590 hasRelatedWork W2014299956 @default.
- W2414464590 hasRelatedWork W2025296888 @default.
- W2414464590 hasRelatedWork W2028155512 @default.
- W2414464590 hasRelatedWork W2045286669 @default.
- W2414464590 hasRelatedWork W2066963718 @default.
- W2414464590 hasRelatedWork W2160265342 @default.
- W2414464590 hasRelatedWork W2428236785 @default.
- W2414464590 hasVolume "23" @default.
- W2414464590 isParatext "false" @default.
- W2414464590 isRetracted "false" @default.
- W2414464590 magId "2414464590" @default.
- W2414464590 workType "article" @default.