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- W2414481488 endingPage "93" @default.
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- W2414481488 abstract "Recently, substantial evidence has emerged that the liver contributes significantly to the circulating levels of follistatin and that circulating follistatin is tightly regulated by the glucagon-to-insulin ratio. Both observations are based on investigations of healthy subjects. These novel findings challenge the present view of circulating follistatin in human physiology, being that circulating follistatin is a result of spill-over from para/autocrine actions in various tissues and cells. Follistatin as a liver-derived protein under the regulation of glucagon-to-insulin ratio suggests a relation to energy metabolism. In this narrative review, we attempt to reconcile the existing findings on circulating follistatin with the novel concept that circulating follistatin is a liver-derived molecule regulated by the glucagon-to-insulin ratio. The picture emerging is that conditions associated with elevated levels of circulating follistatin have a metabolic denominator with decreased insulin sensitivity and/or hyperglucagoneimia." @default.
- W2414481488 created "2016-06-24" @default.
- W2414481488 creator A5021551158 @default.
- W2414481488 creator A5065035537 @default.
- W2414481488 date "2016-09-01" @default.
- W2414481488 modified "2023-10-17" @default.
- W2414481488 title "Circulating follistatin in relation to energy metabolism" @default.
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- W2414481488 doi "https://doi.org/10.1016/j.mce.2016.06.002" @default.
- W2414481488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27264073" @default.
- W2414481488 hasPublicationYear "2016" @default.
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