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• W2414496502 abstract "Sphingoid bases are a group of related aliphatic 2-amino-l,3-diols and characteristic constituents of sphingolipids. The most prevalent base in mammals is sphingenine [D(+)-erythro-2-amino-4-trans-l,3-octadecadecenediol; sphingosine]. The saturated analog, sphinganine (dihydrosphingosine), and the 4-hydroxyderivative of it, 4D-hydroxysphinganine (phytosphingosine), are less common but are major sphingoid bases in other organisms such as plants, invertebrata, fungi, and protozoa. All sphingoid bases found in nature possess the 2D, 3D-configuration, better known as “D-erythro” (in the case of sphingenine or sphinganine), and generally contain 18 carbon atoms. The catabolic removal of sphingoid bases involves a phosphorylation of the primary hydroxyl group, followed by cleavage of the generated phosphorylated sphingoid base (PSB) between the carbon atoms carrying the amino and the secondary hydroxyl groups. The phosphorylation is catalyzed by sphingosine kinase. Mammalian tissues contain a cytosolic and a (presumably plasma) membrane-associated sphingosine kinase, the latter one being responsible for the major portion of the overall tissue activity. The cleavage reaction is catalyzed by sphingosine-1-phosphate lyase (sphingosine-phosphate lyase), also named “dihydrosphingosine-1-phosphate aldolase” or “sphinganine-l-phosphate alkanal lyase” (EC 4.1.2.27). In yeast, this reaction would be the rate-limiting step in sphingolipid breakdown. Interest in PSBs has increased substantially as these zwitterionic lipids appear to evoke different cellular responses. Hence, in addition to being catabolic intermediates, PSBs (especially sphingenine phosphate) are now considered to be inter- and/or intracellular messengers. Whether sphingosine-phosphate lyase plays a role in the attenuation of bioactive sphingenine phosphate has not been critically evaluated, but in mammalian cells a plasma membrane-bound sphingosine phosphatase activity would be involved in the inactivation process." @default.
• W2414496502 created "2016-06-24" @default.
• W2414496502 creator A5084691397 @default.
• W2414496502 date "2000-01-01" @default.
• W2414496502 modified "2023-09-26" @default.
• W2414496502 title "[28] Sphingosine-1-phosphate lyase" @default.
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• W2414496502 doi "https://doi.org/10.1016/s0076-6879(00)11087-0" @default.
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