Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414503235> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2414503235 endingPage "8" @default.
- W2414503235 startingPage "611" @default.
- W2414503235 abstract "Lamivudine (LMV) is still the most commonly used nucleoside analogue in majority of the world. Its administration rapidly leads to resistance associated with mutations in HBV polymerase. THE AIM of the study was to assess the prevalence, nature and the time of LMV resistant variants appearence during a long term therapy.Study was carried out among 175 chronic hepatitis B patients treated with LMV. HBsAg, HBeAg as well as anti-HBe antibodies were detected by enzyme immunosorbent assay and HBV-DNA quantification was performed by RT-PCR. Mutations in HBV polymerase gen were detected by PCR using specific primers and direct sequencing. Liver biopsies were performed in 138 patients to evaluate grading and staging of chronic hepatitis by Scheuer's classification.Mean pre-treatment viral load was comparable among HBeAg-positive and negative patients (4.24 x 10(8) vs. 1.26 x 10(8) IU/ml). Mutations in HBV polymerase gen were detected in 96 patients. After 5 years of LMV therapy the prevalence of mutations was 51.9% in HBeAg-positive and 56.1% in HBeAg-negative. The most common mutations were observed at position 180, followed by 204, 202, and 169 of HBV polymerase gen. After average treatment period of 25 months in HBeAg-positive and 35 months in HBeAg-negative additional mutation 204 was observed in 81% and 77% respectively.Large majority of patients develop point mutations at positions 180 and 204 of HBV polymerase gene after 2 years of treatment with LMV. These mutations limit the efficacy of LMV but also yield cross-resistance with entecavir." @default.
- W2414503235 created "2016-06-24" @default.
- W2414503235 creator A5030935619 @default.
- W2414503235 creator A5042837669 @default.
- W2414503235 creator A5054692461 @default.
- W2414503235 creator A5055667155 @default.
- W2414503235 creator A5058746547 @default.
- W2414503235 creator A5069393179 @default.
- W2414503235 creator A5088271725 @default.
- W2414503235 date "2013-01-01" @default.
- W2414503235 modified "2023-10-17" @default.
- W2414503235 title "HBV mutations associated with lamivudine therapy." @default.
- W2414503235 cites W1978314081 @default.
- W2414503235 cites W1999681805 @default.
- W2414503235 cites W2010585539 @default.
- W2414503235 cites W2050081098 @default.
- W2414503235 cites W2058101157 @default.
- W2414503235 cites W2062462673 @default.
- W2414503235 cites W2065208744 @default.
- W2414503235 cites W2087564721 @default.
- W2414503235 cites W2099690830 @default.
- W2414503235 cites W2121943744 @default.
- W2414503235 cites W2123672919 @default.
- W2414503235 cites W2134970942 @default.
- W2414503235 cites W2143926308 @default.
- W2414503235 cites W2155510029 @default.
- W2414503235 cites W2415056761 @default.
- W2414503235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24741905" @default.
- W2414503235 hasPublicationYear "2013" @default.
- W2414503235 type Work @default.
- W2414503235 sameAs 2414503235 @default.
- W2414503235 citedByCount "1" @default.
- W2414503235 countsByYear W24145032352019 @default.
- W2414503235 crossrefType "journal-article" @default.
- W2414503235 hasAuthorship W2414503235A5030935619 @default.
- W2414503235 hasAuthorship W2414503235A5042837669 @default.
- W2414503235 hasAuthorship W2414503235A5054692461 @default.
- W2414503235 hasAuthorship W2414503235A5055667155 @default.
- W2414503235 hasAuthorship W2414503235A5058746547 @default.
- W2414503235 hasAuthorship W2414503235A5069393179 @default.
- W2414503235 hasAuthorship W2414503235A5088271725 @default.
- W2414503235 hasConcept C104317684 @default.
- W2414503235 hasConcept C159047783 @default.
- W2414503235 hasConcept C176944494 @default.
- W2414503235 hasConcept C2522874641 @default.
- W2414503235 hasConcept C2775940106 @default.
- W2414503235 hasConcept C2777382497 @default.
- W2414503235 hasConcept C2777410769 @default.
- W2414503235 hasConcept C2777869810 @default.
- W2414503235 hasConcept C2780593183 @default.
- W2414503235 hasConcept C49105822 @default.
- W2414503235 hasConcept C501734568 @default.
- W2414503235 hasConcept C54355233 @default.
- W2414503235 hasConcept C71924100 @default.
- W2414503235 hasConcept C82381507 @default.
- W2414503235 hasConcept C86803240 @default.
- W2414503235 hasConceptScore W2414503235C104317684 @default.
- W2414503235 hasConceptScore W2414503235C159047783 @default.
- W2414503235 hasConceptScore W2414503235C176944494 @default.
- W2414503235 hasConceptScore W2414503235C2522874641 @default.
- W2414503235 hasConceptScore W2414503235C2775940106 @default.
- W2414503235 hasConceptScore W2414503235C2777382497 @default.
- W2414503235 hasConceptScore W2414503235C2777410769 @default.
- W2414503235 hasConceptScore W2414503235C2777869810 @default.
- W2414503235 hasConceptScore W2414503235C2780593183 @default.
- W2414503235 hasConceptScore W2414503235C49105822 @default.
- W2414503235 hasConceptScore W2414503235C501734568 @default.
- W2414503235 hasConceptScore W2414503235C54355233 @default.
- W2414503235 hasConceptScore W2414503235C71924100 @default.
- W2414503235 hasConceptScore W2414503235C82381507 @default.
- W2414503235 hasConceptScore W2414503235C86803240 @default.
- W2414503235 hasIssue "4" @default.
- W2414503235 hasLocation W24145032351 @default.
- W2414503235 hasOpenAccess W2414503235 @default.
- W2414503235 hasPrimaryLocation W24145032351 @default.
- W2414503235 hasRelatedWork W1516348686 @default.
- W2414503235 hasRelatedWork W1556816728 @default.
- W2414503235 hasRelatedWork W1912024884 @default.
- W2414503235 hasRelatedWork W1978507788 @default.
- W2414503235 hasRelatedWork W2347701360 @default.
- W2414503235 hasRelatedWork W2382375426 @default.
- W2414503235 hasRelatedWork W2418043455 @default.
- W2414503235 hasRelatedWork W2893706454 @default.
- W2414503235 hasRelatedWork W2953442664 @default.
- W2414503235 hasRelatedWork W3142514864 @default.
- W2414503235 hasVolume "67" @default.
- W2414503235 isParatext "false" @default.
- W2414503235 isRetracted "false" @default.
- W2414503235 magId "2414503235" @default.
- W2414503235 workType "article" @default.