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• W2414508403 abstract "Hearing loss is the most common sensory deficit in humans. Untreated hearing loss will affect speech and language development and lead to impaired cognitive and social skills. Early detection and intervention have proven critical to successful rehabilitation and help individuals with hearing loss to reach their full potential. Since the adoption of universal newborn hearing screening in the United States and other parts of the world, many infants with congenital hearing loss have received a diagnosis shortly after birth and benefited from early intervention programs by 6 months of age, the critical period for language acquisition. However, traditional screening methods have their limitations, including high false positive and false negative rates, difficulty to distinguish transient versus permanent hearing loss, inability to prevent hearing loss presymptomatically, and no etiological explanations. New advances in next-generation sequencing and computing technologies have enabled rapid discoveries of genetic causes of hearing loss. Targeted therapeutic strategies hold the promise for precision medicine to treat hearing loss. Next-generation newborn hearing screening will incorporate comprehensive genomic analyses, which is expected to offer improved sensitivity, specificity, precise etiology, and an earlier window of opportunity for treatment to patients, and to reduce healthcare costs and disparities in society." @default.
• W2414508403 created "2016-06-24" @default.
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• W2414508403 date "2016-04-21" @default.
• W2414508403 modified "2023-09-28" @default.
• W2414508403 title "Next-Generation Newborn Hearing Screening" @default.
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• W2414508403 doi "https://doi.org/10.1159/000444598" @default.
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