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- W2414521946 abstract "Dietary effect of water-soluble derivative- carboxymethyl chitin-glucan (CM-CG) on the level of DNA lesions induced by hydrogen peroxide (H 2 O 2 ) was examined in ex vivo experiments. Lymphocytes, testicular cells, alveolar macrophages and epithelial II cells were isolated from Sprague Dawley rats fed a common or CM-CG enriched diet (200 mg/kg of body weight) during 21 days. Freshly isolated cells were in in vitro conditions exposed to H 2 O 2 and the levels of DNA breaks were evaluated by single cell gel electrophoresis. A dose-dependent increase of DNA breaks was observed after treatment with hydrogen peroxide in all studied cell types. The levels of DNA breaks in cells isolated from CM-CG supplemented animals were lower compared to the levels of DNA breaks in cells isolated from animals fed a common diet. Intake of CM-CG enriched diet did not increase the level of DNA damage in different kinds of freshly isolated rat cells and equipped the cells with resistance to the treatment with hydrogen peroxide." @default.
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- W2414521946 date "2004-01-01" @default.
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- W2414521946 title "Diet containing fungal (1-->3)-beta-D-glucan derivative exhibits protective effects against DNA lesions induced in freshly isolated rat cells." @default.
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