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• W2414536498 abstract "// Kelsie L. Thu 1, * , Mahboubeh Papari-Zareei 2, * , Victor Stastny 2 , Kai Song 2, 3 , Michael Peyton 2 , Victor D. Martinez 1 , Yu-An Zhang 2 , Isabel B. Castro 4 , Marileila Varella-Garcia 4 , Hanquan Liang 5 , Chao Xing 5 , Ralf Kittler 5, 6 , Sara Milchgrub 7 , Diego H. Castrillon 8 , Heather L. Davidson 9 , C Patrick Reynolds 9 , Wan L. Lam 1 , Jayanthi Lea 10 and Adi F. Gazdar 11 1 British Columbia Cancer Agency Research Centre and University of British Columbia, Vancouver, BC, Canada 2 Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA 3 School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China 4 Division of Medical Oncology, University of Colorado Denver School of Medicine, Aurora, CO, USA 5 Eugene McDermott Center for Human Growth & Development, UT Southwestern Medical Center, Dallas, TX, USA 6 Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA 7 Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA 8 Department of Pathology and Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA 9 Cell Biology & Biochemistry, Internal Medicine, and Pediatrics, School of Medicine Texas Tech University Health Sciences Center, Lubbock, TX, USA 10 Obstetrics & Gynecology, UT Southwestern Medical Center, Dallas, TX, USA 11 Hamon Center for Therapeutic Oncology Research, Department of Pathology and Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA * These authors have contributed equally to this work Correspondence to: Adi F. Gazdar, email: adi.gazdar@utsouthwestern.edu Keywords: high-grade serous ovarian carcinoma, cell models, patient-derived xenograft, exome-sequencing, genomic characterization Received: November 14, 2015      Accepted: May 22, 2016      Published: June 10, 2016 ABSTRACT Recent literature suggests that most widely used ovarian cancer (OVCA) cell models do not recapitulate the molecular features of clinical tumors. To address this limitation, we generated 18 cell lines and 3 corresponding patient-derived xenografts predominantly from high-grade serous carcinoma (HGSOC) peritoneal effusions. Comprehensive genomic characterization and comparison of each model to its parental tumor demonstrated a high degree of molecular similarity. Our characterization included whole exome-sequencing and copy number profiling for cell lines, xenografts, and matched non-malignant tissues, and DNA methylation, gene expression, and spectral karyotyping for a subset of specimens. Compared to the Cancer Genome Atlas (TCGA), our models more closely resembled HGSOC than any other tumor type, justifying their validity as OVCA models. Our meticulously characterized models provide a crucial resource for the OVCA research community that will advance translational findings and ultimately lead to clinical applications." @default.
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• W2414536498 date "2016-06-10" @default.
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• W2414536498 title "A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas" @default.
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• W2414536498 doi "https://doi.org/10.18632/oncotarget.9929" @default.
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