Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414538969> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2414538969 endingPage "40" @default.
- W2414538969 startingPage "433" @default.
- W2414538969 abstract "The effect of lipopolysaccharide (LPS) upon the cellular content of mRNA for several enzymes associated with the arachidonic acid cascade was determined in human microvessel-derived endothelial cells. Cells were treated with either vehicle or 10 ng/mL LPS for up to 24 h. Reverse transcription followed by DNA amplification and Southern blotting were used to quantify mRNA for prostaglandin H synthase-1, prostaglandin H synthase-2, cytoplasmic PLA2, and a group II secretory PLA2. LPS treatment resulted in an increase in prostaglandin H synthase-2 mRNA after 4 h with a second peak occurring at 12 h of incubation. The expression of prostaglandin H synthase-1 mRNA was not altered by LPS treatment. An increase in cytoplasmic PLA2 mRNA but not group II PLA2 mRNA was seen after 12 h. These data demonstrate that LPS can increase mRNA production for the inducible form of prostaglandin H synthase and for cytoplasmic PLA2 in a time-dependent manner in human microvessel-derived endothelial cells. These multiple, specific increases in the prostaglandin H synthase-2 and phospholipase A2 mRNA values suggest a complex interaction between bacterial LPS and the endothelial cell eicosanoid system." @default.
- W2414538969 created "2016-06-24" @default.
- W2414538969 creator A5015611006 @default.
- W2414538969 creator A5087713446 @default.
- W2414538969 date "1995-12-01" @default.
- W2414538969 modified "2023-09-23" @default.
- W2414538969 title "Lipopolysaccharide induces time-dependent increases in prostaglandin H synthase-2 and cytosolic phospholipase A2 mRNA in cultured human microvessel-derived endothelial cells." @default.
- W2414538969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8608401" @default.
- W2414538969 hasPublicationYear "1995" @default.
- W2414538969 type Work @default.
- W2414538969 sameAs 2414538969 @default.
- W2414538969 citedByCount "8" @default.
- W2414538969 countsByYear W24145389692013 @default.
- W2414538969 countsByYear W24145389692014 @default.
- W2414538969 countsByYear W24145389692015 @default.
- W2414538969 crossrefType "journal-article" @default.
- W2414538969 hasAuthorship W2414538969A5015611006 @default.
- W2414538969 hasAuthorship W2414538969A5087713446 @default.
- W2414538969 hasConcept C104317684 @default.
- W2414538969 hasConcept C105580179 @default.
- W2414538969 hasConcept C112243037 @default.
- W2414538969 hasConcept C123012128 @default.
- W2414538969 hasConcept C134018914 @default.
- W2414538969 hasConcept C153911025 @default.
- W2414538969 hasConcept C181199279 @default.
- W2414538969 hasConcept C185592680 @default.
- W2414538969 hasConcept C202751555 @default.
- W2414538969 hasConcept C2776352991 @default.
- W2414538969 hasConcept C2776551241 @default.
- W2414538969 hasConcept C2777361909 @default.
- W2414538969 hasConcept C2777956040 @default.
- W2414538969 hasConcept C2778078955 @default.
- W2414538969 hasConcept C2778754761 @default.
- W2414538969 hasConcept C2780664492 @default.
- W2414538969 hasConcept C2780978440 @default.
- W2414538969 hasConcept C55493867 @default.
- W2414538969 hasConcept C86803240 @default.
- W2414538969 hasConceptScore W2414538969C104317684 @default.
- W2414538969 hasConceptScore W2414538969C105580179 @default.
- W2414538969 hasConceptScore W2414538969C112243037 @default.
- W2414538969 hasConceptScore W2414538969C123012128 @default.
- W2414538969 hasConceptScore W2414538969C134018914 @default.
- W2414538969 hasConceptScore W2414538969C153911025 @default.
- W2414538969 hasConceptScore W2414538969C181199279 @default.
- W2414538969 hasConceptScore W2414538969C185592680 @default.
- W2414538969 hasConceptScore W2414538969C202751555 @default.
- W2414538969 hasConceptScore W2414538969C2776352991 @default.
- W2414538969 hasConceptScore W2414538969C2776551241 @default.
- W2414538969 hasConceptScore W2414538969C2777361909 @default.
- W2414538969 hasConceptScore W2414538969C2777956040 @default.
- W2414538969 hasConceptScore W2414538969C2778078955 @default.
- W2414538969 hasConceptScore W2414538969C2778754761 @default.
- W2414538969 hasConceptScore W2414538969C2780664492 @default.
- W2414538969 hasConceptScore W2414538969C2780978440 @default.
- W2414538969 hasConceptScore W2414538969C55493867 @default.
- W2414538969 hasConceptScore W2414538969C86803240 @default.
- W2414538969 hasIssue "6" @default.
- W2414538969 hasLocation W24145389691 @default.
- W2414538969 hasOpenAccess W2414538969 @default.
- W2414538969 hasPrimaryLocation W24145389691 @default.
- W2414538969 hasRelatedWork W1487971131 @default.
- W2414538969 hasRelatedWork W1820398150 @default.
- W2414538969 hasRelatedWork W1967890561 @default.
- W2414538969 hasRelatedWork W1996409233 @default.
- W2414538969 hasRelatedWork W2018889377 @default.
- W2414538969 hasRelatedWork W2084779730 @default.
- W2414538969 hasRelatedWork W2167029659 @default.
- W2414538969 hasRelatedWork W2171416397 @default.
- W2414538969 hasRelatedWork W2410308166 @default.
- W2414538969 hasRelatedWork W781721262 @default.
- W2414538969 hasVolume "4" @default.
- W2414538969 isParatext "false" @default.
- W2414538969 isRetracted "false" @default.
- W2414538969 magId "2414538969" @default.
- W2414538969 workType "article" @default.