Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414542475> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2414542475 endingPage "101" @default.
- W2414542475 startingPage "1098" @default.
- W2414542475 abstract "To investigate the main influence factors of microbubble-enhanced sono-thrombolysis by an orthogonal array experimental design (OAD) and to confirm the optimal parameters of microbubble-enhanced sono-thrombolysis in vitro.The peripheral blood was collected from 50 female Sprague Dawley rats to prepare the standard plasma, and then 100 microL standard plasma and 25 microL thrombin (0.15 U/microL) were mixed and incubated in 37 degrees C water bath for 3, 6, 12, and 24 hours respectively to prepare corresponding standardized thrombus. The physical parameters for the designed experiments included transmit powers of ultrasound (factor A: 5%, 25%, 50%, and 100%), microbubble volume (factor B: 50, 100, 200, and 400 microL), urokinase (UK) concentration (factor C: 100, 200, 400, and 800 U/mL), and thrombolysis time (factor D: 10, 20, 30, and 40 minutes), respectively. Then an OAD based on four parameters and four levels [L16(4(5))] was employed to optimize the thrombolysis conditions. The ultrasound frequency was 1.82 MHz. HE staining and scanning electron microscope (SEM) were used to observe the clots before and after thrombolysis. The thrombolysis rate was measured.HE staining and SEM observation showed that the fibrin was dissolved after thrombolysis. According to the OAD, the optimal parameter combination was C4-D4-A1-B4, indicating UK concentration 800 U/mL, thrombolysis time 40 minutes, transmit power of ultrasound 5%, and microbubble volume 400 microL, respectively. The four factors above had significant influence on thrombolysis (P < 0.05), and UK concentration was the most significant. There were significant differences in thrombolysis between different thrombolysis time (P < 0.05).Under the condition of fixed ultrasound frequency, microbubble-enhanced sono-thrombolysis efficiency is better in lower transmit power of ultrasound, higher UK concentration, longer thrombolysis time, higher microbubble volume, and shorter thrombolysis time." @default.
- W2414542475 created "2016-06-24" @default.
- W2414542475 creator A5014674611 @default.
- W2414542475 creator A5033188728 @default.
- W2414542475 creator A5037732917 @default.
- W2414542475 creator A5057485876 @default.
- W2414542475 creator A5063089557 @default.
- W2414542475 creator A5082859611 @default.
- W2414542475 creator A5090541335 @default.
- W2414542475 date "2012-09-01" @default.
- W2414542475 modified "2023-09-22" @default.
- W2414542475 title "[Orthogonal analysis of physical parameters optimization of microbubble-enhanced sono-thrombolysis]." @default.
- W2414542475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23057357" @default.
- W2414542475 hasPublicationYear "2012" @default.
- W2414542475 type Work @default.
- W2414542475 sameAs 2414542475 @default.
- W2414542475 citedByCount "0" @default.
- W2414542475 crossrefType "journal-article" @default.
- W2414542475 hasAuthorship W2414542475A5014674611 @default.
- W2414542475 hasAuthorship W2414542475A5033188728 @default.
- W2414542475 hasAuthorship W2414542475A5037732917 @default.
- W2414542475 hasAuthorship W2414542475A5057485876 @default.
- W2414542475 hasAuthorship W2414542475A5063089557 @default.
- W2414542475 hasAuthorship W2414542475A5082859611 @default.
- W2414542475 hasAuthorship W2414542475A5090541335 @default.
- W2414542475 hasConcept C126322002 @default.
- W2414542475 hasConcept C126838900 @default.
- W2414542475 hasConcept C136229726 @default.
- W2414542475 hasConcept C143753070 @default.
- W2414542475 hasConcept C185592680 @default.
- W2414542475 hasConcept C203014093 @default.
- W2414542475 hasConcept C2776825266 @default.
- W2414542475 hasConcept C2779581417 @default.
- W2414542475 hasConcept C2989005 @default.
- W2414542475 hasConcept C500558357 @default.
- W2414542475 hasConcept C54173615 @default.
- W2414542475 hasConcept C71924100 @default.
- W2414542475 hasConceptScore W2414542475C126322002 @default.
- W2414542475 hasConceptScore W2414542475C126838900 @default.
- W2414542475 hasConceptScore W2414542475C136229726 @default.
- W2414542475 hasConceptScore W2414542475C143753070 @default.
- W2414542475 hasConceptScore W2414542475C185592680 @default.
- W2414542475 hasConceptScore W2414542475C203014093 @default.
- W2414542475 hasConceptScore W2414542475C2776825266 @default.
- W2414542475 hasConceptScore W2414542475C2779581417 @default.
- W2414542475 hasConceptScore W2414542475C2989005 @default.
- W2414542475 hasConceptScore W2414542475C500558357 @default.
- W2414542475 hasConceptScore W2414542475C54173615 @default.
- W2414542475 hasConceptScore W2414542475C71924100 @default.
- W2414542475 hasIssue "9" @default.
- W2414542475 hasLocation W24145424751 @default.
- W2414542475 hasOpenAccess W2414542475 @default.
- W2414542475 hasPrimaryLocation W24145424751 @default.
- W2414542475 hasRelatedWork W1963973205 @default.
- W2414542475 hasRelatedWork W1968767704 @default.
- W2414542475 hasRelatedWork W2027940641 @default.
- W2414542475 hasRelatedWork W2049830469 @default.
- W2414542475 hasRelatedWork W2060027938 @default.
- W2414542475 hasRelatedWork W2064502952 @default.
- W2414542475 hasRelatedWork W2129172331 @default.
- W2414542475 hasRelatedWork W2311216190 @default.
- W2414542475 hasRelatedWork W2769932627 @default.
- W2414542475 hasRelatedWork W3151644628 @default.
- W2414542475 hasVolume "26" @default.
- W2414542475 isParatext "false" @default.
- W2414542475 isRetracted "false" @default.
- W2414542475 magId "2414542475" @default.
- W2414542475 workType "article" @default.