Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414542988> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2414542988 endingPage "32" @default.
- W2414542988 startingPage "415" @default.
- W2414542988 abstract "The cell death is a natural physiological process that occurs in every living organism. It is clear that programmed cell death--apoptosis--is an important mechanism maintaining cell number in a multicellular organism. This review summarises recent progress in the field of apoptosis. Extracellular signals, such as various growth factors and antigen Fas ligand can trigger apoptosis via cell surface receptors. Within the cell the tumor suppressor gene p53 and oncogenes c-myc, c-fos and c-jun tend to activate apoptosis, while other genes such as most members of the bcl-2 family, tend to suppress it. Many of these signals regulate a family of cysteine proteases--related to interleukin 1 beta converting enzyme (ICE)--caspases--which play a crucial role in apoptosis. Many factors that affect apoptosis also affect the cell cycle. For example, p53 appears to be an important mediator of both apoptosis and cycle arrest. If DNA damage is repaired during cycle arrest, the cell survives. Special attention is paid to the abnormalities in the regulation of apoptosis that may contribute to different pathogenic processes." @default.
- W2414542988 created "2016-06-24" @default.
- W2414542988 creator A5028165911 @default.
- W2414542988 creator A5075276071 @default.
- W2414542988 creator A5078035175 @default.
- W2414542988 date "1998-01-01" @default.
- W2414542988 modified "2023-09-23" @default.
- W2414542988 title "[The role of apoptosis in cell physiology and pathology]." @default.
- W2414542988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10224887" @default.
- W2414542988 hasPublicationYear "1998" @default.
- W2414542988 type Work @default.
- W2414542988 sameAs 2414542988 @default.
- W2414542988 citedByCount "2" @default.
- W2414542988 countsByYear W24145429882018 @default.
- W2414542988 crossrefType "journal-article" @default.
- W2414542988 hasAuthorship W2414542988A5028165911 @default.
- W2414542988 hasAuthorship W2414542988A5075276071 @default.
- W2414542988 hasAuthorship W2414542988A5078035175 @default.
- W2414542988 hasConcept C1491633281 @default.
- W2414542988 hasConcept C163421366 @default.
- W2414542988 hasConcept C181199279 @default.
- W2414542988 hasConcept C182220744 @default.
- W2414542988 hasConcept C190283241 @default.
- W2414542988 hasConcept C29537977 @default.
- W2414542988 hasConcept C3031857 @default.
- W2414542988 hasConcept C31573885 @default.
- W2414542988 hasConcept C54355233 @default.
- W2414542988 hasConcept C55493867 @default.
- W2414542988 hasConcept C56483683 @default.
- W2414542988 hasConcept C74318829 @default.
- W2414542988 hasConcept C86803240 @default.
- W2414542988 hasConcept C95444343 @default.
- W2414542988 hasConcept C98424977 @default.
- W2414542988 hasConceptScore W2414542988C1491633281 @default.
- W2414542988 hasConceptScore W2414542988C163421366 @default.
- W2414542988 hasConceptScore W2414542988C181199279 @default.
- W2414542988 hasConceptScore W2414542988C182220744 @default.
- W2414542988 hasConceptScore W2414542988C190283241 @default.
- W2414542988 hasConceptScore W2414542988C29537977 @default.
- W2414542988 hasConceptScore W2414542988C3031857 @default.
- W2414542988 hasConceptScore W2414542988C31573885 @default.
- W2414542988 hasConceptScore W2414542988C54355233 @default.
- W2414542988 hasConceptScore W2414542988C55493867 @default.
- W2414542988 hasConceptScore W2414542988C56483683 @default.
- W2414542988 hasConceptScore W2414542988C74318829 @default.
- W2414542988 hasConceptScore W2414542988C86803240 @default.
- W2414542988 hasConceptScore W2414542988C95444343 @default.
- W2414542988 hasConceptScore W2414542988C98424977 @default.
- W2414542988 hasIssue "4" @default.
- W2414542988 hasLocation W24145429881 @default.
- W2414542988 hasOpenAccess W2414542988 @default.
- W2414542988 hasPrimaryLocation W24145429881 @default.
- W2414542988 hasRelatedWork W1563544530 @default.
- W2414542988 hasRelatedWork W2007612684 @default.
- W2414542988 hasRelatedWork W2015424171 @default.
- W2414542988 hasRelatedWork W2145626047 @default.
- W2414542988 hasRelatedWork W22589161 @default.
- W2414542988 hasRelatedWork W2378071104 @default.
- W2414542988 hasRelatedWork W2389372423 @default.
- W2414542988 hasRelatedWork W2414542988 @default.
- W2414542988 hasRelatedWork W2809736157 @default.
- W2414542988 hasRelatedWork W3134974964 @default.
- W2414542988 hasVolume "49" @default.
- W2414542988 isParatext "false" @default.
- W2414542988 isRetracted "false" @default.
- W2414542988 magId "2414542988" @default.
- W2414542988 workType "article" @default.