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• W2414642281 abstract "Aim: It was the aim of this study to synthesize pectin (PEC) with sulfhydryl groups and evaluate its suitability in buccal application. Materials & methods: Native PEC was chemically modified by covalent attachment of sulfhydryl-bearing cysteine (CYS). Stability assays in form of water uptake behavior and erosion study were performed. Additionally, mucoadhesive study on buccal mucosa was performed. Results: Pectin–cysteine (PECCYS) was successfully synthesized as proved by IR and Ellman's assay exhibiting 436.59 ± 127.87 µmol thiol groups per gram polymer. Stability assay showed that PECCYS revealed a 2.27-fold improved water uptake and mucoadhesiveness augmented 3.75-fold in comparison to unmodified PEC. Conclusion: PECCYS might be a future suitable excipient for buccal adhesive application." @default.
• W2414642281 created "2016-06-24" @default.
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• W2414642281 date "2016-06-01" @default.
• W2414642281 modified "2023-10-06" @default.
• W2414642281 title "Design, modification and in vitro evaluation of pectin's bucco-adhesiveness" @default.
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• W2414642281 doi "https://doi.org/10.4155/tde-2016-0019" @default.
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