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- W2414654587 abstract "The clinical significance and public health implications for HIV pathogenesis due to resistance to antiretroviral agents, such as AZT, ddI, ddC, d4T, 3TC, are discussed. Several studies are highlighted, showing that AZT resistance is associated with more rapid clinical progression and death. AZT-resistant viruses are quite tough, and once established, become the dominant circulating quasi-species. Other studies show that the clinical significance of resistance to the dideoxynucleosides (ddI, ddC, d4T, and 3TC) remains incompletely understood. The article notes that, despite widespread clinical practice of using combination treatment regimens, no study has proven that combination therapy delays HIV disease progression or death over the long term. Public health considerations include the proven problem of human- to-human transmission of AZT-resistant HIV." @default.
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- W2414654587 date "1995-08-01" @default.
- W2414654587 modified "2023-09-23" @default.
- W2414654587 title "Antiretroviral drug resistance." @default.
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