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- W2414682751 abstract "Basal serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) and the responsiveness of these hormones to a challenge dose of luteinizing hormone releasing hormone (LHRH), were determined in juvenile, pubertal, and adult rhesus monkeys. The monkey gonadotrophins were analyzed using RIA reagents supplied by the World Health Organization (WHO) Special Programme of Human Reproduction. The FSH levels which were near the assay sensitivity in immature monkeys (2.4 ± 0.8 ng/ml) showed a discernible increase in pubertal animals (6.4 ± 1.8 ng/ml). Compared to other two age groups, the serum FSH concentration was markedly higher (16.1 ± 1.8 ng/ml) in adults. Serum LH levels were below the detectable limits of the assay in juvenile monkeys but rose to 16.2 ± 3.1 ng/ml in pubertal animals. When compared to pubertal animals, a two‐fold increase in LH levels paralleled changes in serum LH during the three developmental stages. Response of serum gonadotrophins and T levels to a challenge dose of LHRH (2.5 μg; i.v.) was variable in the different age groups. The present data suggest: (1) an asynchronous rise of FSH and LH during the pubertal period and a temporal correlation between the testicular size and FSH concentrations; (2) the challenge dose of LHRH, which induces a significant rise in serum LH and T levels, fails to elicit an FSH response in all the three age groups; and (3) the pubertal as compared to adult monkeys release significantly larger quantities of LH in response to exogenous LHRH." @default.
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- W2414682751 date "1986-10-01" @default.
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- W2414682751 title "Changes in Circulating Levels of Immunoreactive Follicle Stimulating Hormone, Luteinizing Hormone, and Testosterone During Sexual Development in the Rhesus Monkey, Macaca mulatta" @default.
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- W2414682751 doi "https://doi.org/10.1111/j.1600-0684.1986.tb00405.x" @default.
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