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- W2414698145 abstract "Tetrandrine (Tet) 64 μM and verapamil (Ver) 8.4 μM relaxed the contraction of coronary artery strips. It is reversed by raising the extracellular Ca++ from 2.7 to 14.4 mM. Within a certain range (Tet 0. 1 μM 0.1 mM, Ver 1 nM 1 μM) the percentage of relaxation was in proportion to the dose. However, Tet and Ver exert no significant inhibition on the extracellular Ca++-dependent contraction induced by norepinephrine (NE). Probably Tet and Ver primarily inhibited the potential-dependent channel (PDC) and prevented the influx of Ca++ through PDC. Tet 10 μM and Ver 0.1 μM also inhibited the release of intracellular Ca++ by NE. This shows that Tet and Ver might affect the transport of the intracellular Ca++. The relaxant effect of isoproterenol on the coronary strips was not blocked by Tet and Ver. Tet is therefore considered to be different from the β-blocker propranolol but similar to the calcium antagonist Ver." @default.
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- W2414698145 date "1985-03-01" @default.
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- W2414698145 title "Studies on the calcium antagonistic action of tetrandrine: IX. Effects of tetrandrine on contractility of isolated swine coronary artery strips" @default.
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- W2414698145 doi "https://doi.org/10.1007/bf02856904" @default.
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