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- W2414708927 abstract "The primary function of the lymphatic system is to drain ~10% of the interstitial fluid from small capillaries to lymphatic vessels through lymph nodes (LNs) and finally to the venous system (1-5). LNs form a natural filter for lymphatic drainage and prevent the possible migration of cancer cells from the lymphatic system into the body. As the first LN that receives lymph drainage from a tumor bed, the sentinel LN is very likely to contain cancer cells if the primary tumor has spread via the lymphatic system (1, 2). The lymphatic system is complex, and its detection and mapping remain challenging (1, 2, 6, 7). However, with advances of new imaging agents and techniques, imaging and mapping of both the lymphatic vessels and the LNs are now possible with x-ray–computed tomography, ultrasound, nuclear medicine, and magnetic resonance imaging (7-9). There is increasing evidence that tumor cells induce lymphangiogenesis in tumor-draining LNs in experimental models of cancer (10, 11) as well as in LNs of patients with metastatic melanoma and breast cancer (12, 13). Therefore, LN lymphangiogenesis might provide a target to image the early stages of tumor metastasis. In addition, chronic inflamed tissues produce vascular endothelial growth factor (VEGF) to induce lymphangiogenesis in draining LNs.Hyaluronan (HA) is an abundant extracellular matrix glycosaminoglycan in skin and mesenchymal tissues, where it facilitates cell migration during inflammation, wound healing, metastasis, and embryonic morphogenesis (14, 15). CD44 is an integral cell membrane glycoprotein on leukocytes and has an important role in matrix adhesion lymphocyte activation and LN homing (16). CD44 binds HA to induce extravasation of lymphoid cells. Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) has a 41% homology to CD44, and LYVE-1 expression is largely restricted to endothelial cells of lymphatic vessels and splenic sinusoidal endothelial cells. Expression was undetectable on lymphocytes, hematopoietic cells, or vascular endothelial cells. Mumprecht et al. (17) used 124I-labeled antibody against LYVE-1 (124I-anti-LYVE-1) for in vivo imaging of inflammation- and tumor-induced LN lymphangiogenesis with positron emission tomography (PET)." @default.
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- W2414708927 date "2011-07-06" @default.
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- W2414708927 title "124I-Labeled antibody against lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)" @default.
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