Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414721504> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2414721504 endingPage "6" @default.
- W2414721504 startingPage "312" @default.
- W2414721504 abstract "To investigate the effect of PARP1 inhibitor PJ34 on multi-drug resistance in a human multiple myeloma cell line and its connection with FA/BRCA pathway in DNA damage repair.A CCK8 assay was used to measure the inhibition rate. Real-time quantitative PCR was used to detect expression changes of DNA repair genes involved in the FA/BRCA pathway. Western blotting assay was used to detect expression of key protein FANCD2 in the FA/BRCA pathway. Annexin VFITC/PI double staining flow cytometry was used to measure cell apoptosis induced by PJ34. A COMET assay was used to detect the effect of PJ34 on DNA damage repair.PJ34 could significantly enhance the sensitivity of RPMI8226/R cells to melphalan. The IC50 value of melphalan was dropped from 20.43 mol/L to 7.8 mol/L. PJ34 could inhibit the DNA damage repair, and the effect was related with the inhibition of FA/BRCA pathway. PJ34 and melphalan showed a synergistic effect in promoting the apoptosis of RPMI8226/R cells.PJ34 can reverse the resistance of RPMI8226/R cells to melphalan by inhibiting the FA/BRCA pathway, which in turn can induce suppression of DNA damage repair. Therefore, PJ34 may have clinical value in overcoming the multi-drug resistance of multiple myeloma." @default.
- W2414721504 created "2016-06-24" @default.
- W2414721504 creator A5034323855 @default.
- W2414721504 creator A5038164902 @default.
- W2414721504 creator A5047350158 @default.
- W2414721504 creator A5073951362 @default.
- W2414721504 date "2014-06-01" @default.
- W2414721504 modified "2023-09-25" @default.
- W2414721504 title "[Effect of PARP1 inhibitor PJ34 on multi-drug resistance in human multiple myeloma cell line and its relationship with FA/BRCA pathway]." @default.
- W2414721504 doi "https://doi.org/10.3760/cma.j.issn.1003-9406.2014.03.012" @default.
- W2414721504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24928009" @default.
- W2414721504 hasPublicationYear "2014" @default.
- W2414721504 type Work @default.
- W2414721504 sameAs 2414721504 @default.
- W2414721504 citedByCount "0" @default.
- W2414721504 crossrefType "journal-article" @default.
- W2414721504 hasAuthorship W2414721504A5034323855 @default.
- W2414721504 hasAuthorship W2414721504A5038164902 @default.
- W2414721504 hasAuthorship W2414721504A5047350158 @default.
- W2414721504 hasAuthorship W2414721504A5073951362 @default.
- W2414721504 hasConcept C104317684 @default.
- W2414721504 hasConcept C134935766 @default.
- W2414721504 hasConcept C143425029 @default.
- W2414721504 hasConcept C153911025 @default.
- W2414721504 hasConcept C182979987 @default.
- W2414721504 hasConcept C185592680 @default.
- W2414721504 hasConcept C190283241 @default.
- W2414721504 hasConcept C203014093 @default.
- W2414721504 hasConcept C2776364478 @default.
- W2414721504 hasConcept C2778480876 @default.
- W2414721504 hasConcept C2778684742 @default.
- W2414721504 hasConcept C2780358455 @default.
- W2414721504 hasConcept C502942594 @default.
- W2414721504 hasConcept C54355233 @default.
- W2414721504 hasConcept C552990157 @default.
- W2414721504 hasConcept C553184892 @default.
- W2414721504 hasConcept C55493867 @default.
- W2414721504 hasConcept C81885089 @default.
- W2414721504 hasConcept C82381507 @default.
- W2414721504 hasConcept C85265743 @default.
- W2414721504 hasConcept C86803240 @default.
- W2414721504 hasConceptScore W2414721504C104317684 @default.
- W2414721504 hasConceptScore W2414721504C134935766 @default.
- W2414721504 hasConceptScore W2414721504C143425029 @default.
- W2414721504 hasConceptScore W2414721504C153911025 @default.
- W2414721504 hasConceptScore W2414721504C182979987 @default.
- W2414721504 hasConceptScore W2414721504C185592680 @default.
- W2414721504 hasConceptScore W2414721504C190283241 @default.
- W2414721504 hasConceptScore W2414721504C203014093 @default.
- W2414721504 hasConceptScore W2414721504C2776364478 @default.
- W2414721504 hasConceptScore W2414721504C2778480876 @default.
- W2414721504 hasConceptScore W2414721504C2778684742 @default.
- W2414721504 hasConceptScore W2414721504C2780358455 @default.
- W2414721504 hasConceptScore W2414721504C502942594 @default.
- W2414721504 hasConceptScore W2414721504C54355233 @default.
- W2414721504 hasConceptScore W2414721504C552990157 @default.
- W2414721504 hasConceptScore W2414721504C553184892 @default.
- W2414721504 hasConceptScore W2414721504C55493867 @default.
- W2414721504 hasConceptScore W2414721504C81885089 @default.
- W2414721504 hasConceptScore W2414721504C82381507 @default.
- W2414721504 hasConceptScore W2414721504C85265743 @default.
- W2414721504 hasConceptScore W2414721504C86803240 @default.
- W2414721504 hasIssue "3" @default.
- W2414721504 hasLocation W24147215041 @default.
- W2414721504 hasOpenAccess W2414721504 @default.
- W2414721504 hasPrimaryLocation W24147215041 @default.
- W2414721504 hasRelatedWork W1914298319 @default.
- W2414721504 hasRelatedWork W1927227616 @default.
- W2414721504 hasRelatedWork W2036747859 @default.
- W2414721504 hasRelatedWork W2080479901 @default.
- W2414721504 hasRelatedWork W2107296733 @default.
- W2414721504 hasRelatedWork W2374397084 @default.
- W2414721504 hasRelatedWork W2414721504 @default.
- W2414721504 hasRelatedWork W2611726530 @default.
- W2414721504 hasRelatedWork W4223917195 @default.
- W2414721504 hasRelatedWork W2766534665 @default.
- W2414721504 hasVolume "31" @default.
- W2414721504 isParatext "false" @default.
- W2414721504 isRetracted "false" @default.
- W2414721504 magId "2414721504" @default.
- W2414721504 workType "article" @default.