FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414779408> ?p ?o ?g. }

• W2414779408 endingPage "1516" @default.
• W2414779408 startingPage "1508" @default.
• W2414779408 abstract "Furan, a possible human carcinogen, is found in heat treated foods and tobacco smoke. Previous studies have shown that humans are capable of converting furan to its reactive metabolite, cis-2-butene-1,4-dial (BDA), and therefore may be susceptible to furan toxicity. Human risk assessment of furan exposure has been stymied because of the lack of mechanism-based exposure biomarkers. Therefore, a sensitive LC-MS/MS assay for six furan metabolites was applied to measure their levels in urine from furan-exposed rodents as well as in human urine from smokers and nonsmokers. The metabolites that result from direct reaction of BDA with lysine (BDA-N(α)-acetyllysine) and from cysteine-BDA-lysine cross-links (N-acetylcysteine-BDA-lysine, N-acetylcysteine-BDA-N(α)-acetyllysine, and their sulfoxides) were targeted in this study. Five of the six metabolites were identified in urine from rodents treated with furan by gavage. BDA-N(α)-acetyllysine, N-acetylcysteine-BDA-lysine, and its sulfoxide were detected in most human urine samples from three different groups. The levels of N-acetylcysteine-BDA-lysine sulfoxide were more than 10 times higher than that of the corresponding sulfide in many samples. The amount of this metabolite was higher in smokers relative to that in nonsmokers and was significantly reduced following smoking cessation. Our results indicate a strong relationship between BDA-derived metabolites and smoking. Future studies will determine if levels of these biomarkers are associated with adverse health effects in humans." @default.
• W2414779408 created "2016-06-24" @default.
• W2414779408 creator A5013305361 @default.
• W2414779408 creator A5022126431 @default.
• W2414779408 creator A5035351828 @default.
• W2414779408 creator A5037811012 @default.
• W2414779408 creator A5061577144 @default.
• W2414779408 creator A5085576804 @default.
• W2414779408 creator A5086584602 @default.
• W2414779408 creator A5088242752 @default.
• W2414779408 date "2015-07-07" @default.
• W2414779408 modified "2023-10-18" @default.
• W2414779408 title "Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans" @default.
• W2414779408 cites W1965169484 @default.
• W2414779408 cites W1966239409 @default.
• W2414779408 cites W1967830845 @default.
• W2414779408 cites W1968744886 @default.
• W2414779408 cites W1971679392 @default.
• W2414779408 cites W1975414280 @default.
• W2414779408 cites W1983279352 @default.
• W2414779408 cites W1996843484 @default.
• W2414779408 cites W1999898828 @default.
• W2414779408 cites W2003388341 @default.
• W2414779408 cites W2007038836 @default.
• W2414779408 cites W2014467653 @default.
• W2414779408 cites W2018874269 @default.
• W2414779408 cites W2027095027 @default.
• W2414779408 cites W2028480663 @default.
• W2414779408 cites W2029007583 @default.
• W2414779408 cites W2032303437 @default.
• W2414779408 cites W2032979359 @default.
• W2414779408 cites W2036641927 @default.
• W2414779408 cites W2042259218 @default.
• W2414779408 cites W2044122549 @default.
• W2414779408 cites W2047125250 @default.
• W2414779408 cites W2047761239 @default.
• W2414779408 cites W2048614683 @default.
• W2414779408 cites W2049073921 @default.
• W2414779408 cites W2054014484 @default.
• W2414779408 cites W2057749448 @default.
• W2414779408 cites W2061322294 @default.
• W2414779408 cites W2067288183 @default.
• W2414779408 cites W2077458096 @default.
• W2414779408 cites W2079709169 @default.
• W2414779408 cites W2087676721 @default.
• W2414779408 cites W2093683863 @default.
• W2414779408 cites W2110616972 @default.
• W2414779408 cites W2122179629 @default.
• W2414779408 cites W2126645982 @default.
• W2414779408 cites W2131633435 @default.
• W2414779408 cites W2136546690 @default.
• W2414779408 cites W2137684408 @default.
• W2414779408 cites W2142548722 @default.
• W2414779408 cites W2166804833 @default.
• W2414779408 cites W2171924267 @default.
• W2414779408 cites W2185675491 @default.
• W2414779408 cites W2411365253 @default.
• W2414779408 cites W4299498680 @default.
• W2414779408 doi "https://doi.org/10.1021/acs.chemrestox.5b00189" @default.
• W2414779408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5473163" @default.
• W2414779408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26114498" @default.
• W2414779408 hasPublicationYear "2015" @default.
• W2414779408 type Work @default.
• W2414779408 sameAs 2414779408 @default.
• W2414779408 citedByCount "24" @default.
• W2414779408 countsByYear W24147794082015 @default.
• W2414779408 countsByYear W24147794082016 @default.
• W2414779408 countsByYear W24147794082017 @default.
• W2414779408 countsByYear W24147794082018 @default.
• W2414779408 countsByYear W24147794082019 @default.
• W2414779408 countsByYear W24147794082020 @default.
• W2414779408 countsByYear W24147794082021 @default.
• W2414779408 countsByYear W24147794082022 @default.
• W2414779408 countsByYear W24147794082023 @default.
• W2414779408 crossrefType "journal-article" @default.
• W2414779408 hasAuthorship W2414779408A5013305361 @default.
• W2414779408 hasAuthorship W2414779408A5022126431 @default.
• W2414779408 hasAuthorship W2414779408A5035351828 @default.
• W2414779408 hasAuthorship W2414779408A5037811012 @default.
• W2414779408 hasAuthorship W2414779408A5061577144 @default.
• W2414779408 hasAuthorship W2414779408A5085576804 @default.
• W2414779408 hasAuthorship W2414779408A5086584602 @default.
• W2414779408 hasAuthorship W2414779408A5088242752 @default.
• W2414779408 hasBestOaLocation W24147794082 @default.
• W2414779408 hasConcept C114246631 @default.
• W2414779408 hasConcept C178790620 @default.
• W2414779408 hasConcept C185592680 @default.
• W2414779408 hasConcept C2776016237 @default.
• W2414779408 hasConcept C2777477808 @default.
• W2414779408 hasConcept C2778355491 @default.
• W2414779408 hasConcept C2778448320 @default.
• W2414779408 hasConcept C2778659115 @default.
• W2414779408 hasConcept C2780026642 @default.
• W2414779408 hasConcept C29730261 @default.
• W2414779408 hasConcept C515207424 @default.
• W2414779408 hasConcept C55493867 @default.
• W2414779408 hasConcept C71924100 @default.
• W2414779408 hasConcept C98274493 @default.

• next