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- W2414786403 abstract "Abstract A simple, precise, and rapid LC/MS/MS method was developed and validated for the quantification of emtricitabine in human plasma using lamivudine as the internal standard (IS). The method involves liquidliquid extraction of emtricitabine and the IS in diethyl etherethyl acetate (50 + 50, v/v) from 0.1 mL human plasma. A Kromasil C18 (150 4.6 mm, 5 m particle size) analytical column was used for the chromatographic separation under isocratic conditions. The parent product ion transitions for emtricitabine (m/z 248.0130.0) and the IS (m/z 230.1 112.0) were monitored on a triple-quadrupole mass spectrometer, operated in the multiple reaction monitoring positive ion mode. The method was validated over the concentration range of 29.23110 ng/mL for emtricitabine, with a total chromatographic run time of 1.5 min. Acceptable precision and accuracy were obtained for the concentrations used to prepare the standard curves. The applicability of the method was demonstrated by a pharmacokinetic study conducted with 43 healthy volunteers who were administered a capsule formulation containing 200 mg emtricitabine." @default.
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- W2414786403 date "2009-11-01" @default.
- W2414786403 modified "2023-09-24" @default.
- W2414786403 title "Microdetermination of Emtricitabine in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry" @default.
- W2414786403 doi "https://doi.org/10.1093/jaoac/92.6.1681" @default.
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