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- W2414837029 abstract "The experiments performed in endothelin-denuded preparations (the strips of thoracic aorta and perfused tail arteries) showed that: 1) ET-1 exerts dose-dependent and slowly developing contractions and in subthreshold doses it potentiates vasoconstriction reactions to stimulate sympathetic nerve endings or phenylephrine exposure. 2) ion F(-), that activates G-proteins in the cell membranes, at a dose of 2 microM increased about two times the ET-1-induced vasoconstriction. 3) the aortic strip incubation with the protein kinase C inhibitor staurosporin led to a 50% decrease in the contraction amplitude. Results suggest that G proteins and protein kinase C may participate in the development of ET-1 induced vascular smooth muscle contraction." @default.
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- W2414837029 date "1993-10-01" @default.
- W2414837029 modified "2023-09-24" @default.
- W2414837029 title "[The effect of endothelin-1 on vascular adrenoreactivity. The participation of G-proteins and protein kinase C in vascular constriction under the action of endothelin-1]." @default.
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