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• W2414895979 abstract "Abstract Hip fracture surgery carries a high risk of venous thromboembolism and, until recently, was poorly investigated. The efficacy and safety of fondaparinux, a new synthetic antithrombotic, were investigated in two large, thromboprophylaxis studies. Results of the Penthifra study, which was a randomized, double-blind phase III trial, showed that 1 week of fondaparinux, compared with enoxaparin, significantly reduced venous thromboembolic events from 19.1% to 8.3% (relative risk reduction: 56.4%; P<.001) without increasing bleeding risk. Penthifra Plus results showed that extending fondaparinux prophylaxis from 1 to 4 weeks was well tolerated and, compared to placebo, significantly reduced delayed venous thromboembolism events from 35% to 1 .4% (relative risk reduction: 95.9%; P<.001). Based on these findings, 4-week fondaparinux treatment may become the standard thromboprophylaxis after hip fracture surgery." @default.
• W2414895979 created "2016-06-24" @default.
• W2414895979 creator A5083647812 @default.
• W2414895979 date "2003-08-01" @default.
• W2414895979 modified "2023-09-26" @default.
• W2414895979 title "Improvements in the Prevention of Postoperative Venous Thromboembolism in Hip Fracture Patients" @default.
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• W2414895979 doi "https://doi.org/10.3928/0147-7447-20030802-06" @default.
• W2414895979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12934740" @default.
• W2414895979 hasPublicationYear "2003" @default.
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