Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414897195> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2414897195 endingPage "83" @default.
- W2414897195 startingPage "269" @default.
- W2414897195 abstract "The preparation and properties of cathepsin D from rat liver are reported. The enzyme is an endopeptidase of lysosomal origin. The molecular weight was estimated to be 49000 by sodium-dodecylsulfate electrophoresis. We did not find any dissociation into subunits under reducing conditions, in contrast to some other authors. We found the enzyme to occur in at least 4 forms with the isoelectric points 5.87, 5.65, 5.41 and 5.13. Strong -SH-blocking reagents inhibit the activity, but the most powerful and specific inhibitor was pepstatin (Ki=38 nM). The substrate specificity is discussed. There was no proof for any zymogen activation in a great number of experiments. Since the cathepsins B1, B3 and L obviously seem to play the major role in the intracellular protein breakdown within the rat liver, the main task of cathepsin D is the degradation of extracellular proteins in this organ." @default.
- W2414897195 created "2016-06-24" @default.
- W2414897195 creator A5021024316 @default.
- W2414897195 creator A5029496265 @default.
- W2414897195 creator A5044675210 @default.
- W2414897195 creator A5051807083 @default.
- W2414897195 creator A5053797588 @default.
- W2414897195 creator A5082331456 @default.
- W2414897195 date "1976-01-01" @default.
- W2414897195 modified "2023-09-23" @default.
- W2414897195 title "[Intracellular protein breakdown. VI. Isolation, properties and biological significance of cathepsin D from rat liver]." @default.
- W2414897195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9765" @default.
- W2414897195 hasPublicationYear "1976" @default.
- W2414897195 type Work @default.
- W2414897195 sameAs 2414897195 @default.
- W2414897195 citedByCount "4" @default.
- W2414897195 crossrefType "journal-article" @default.
- W2414897195 hasAuthorship W2414897195A5021024316 @default.
- W2414897195 hasAuthorship W2414897195A5029496265 @default.
- W2414897195 hasAuthorship W2414897195A5044675210 @default.
- W2414897195 hasAuthorship W2414897195A5051807083 @default.
- W2414897195 hasAuthorship W2414897195A5053797588 @default.
- W2414897195 hasAuthorship W2414897195A5082331456 @default.
- W2414897195 hasConcept C104810894 @default.
- W2414897195 hasConcept C153911025 @default.
- W2414897195 hasConcept C167844969 @default.
- W2414897195 hasConcept C173633252 @default.
- W2414897195 hasConcept C181199279 @default.
- W2414897195 hasConcept C185592680 @default.
- W2414897195 hasConcept C2776350231 @default.
- W2414897195 hasConcept C2776714187 @default.
- W2414897195 hasConcept C2777774944 @default.
- W2414897195 hasConcept C2778775115 @default.
- W2414897195 hasConcept C28021979 @default.
- W2414897195 hasConcept C28406088 @default.
- W2414897195 hasConcept C50476208 @default.
- W2414897195 hasConcept C55493867 @default.
- W2414897195 hasConcept C78553746 @default.
- W2414897195 hasConcept C79879829 @default.
- W2414897195 hasConcept C86803240 @default.
- W2414897195 hasConcept C96294017 @default.
- W2414897195 hasConceptScore W2414897195C104810894 @default.
- W2414897195 hasConceptScore W2414897195C153911025 @default.
- W2414897195 hasConceptScore W2414897195C167844969 @default.
- W2414897195 hasConceptScore W2414897195C173633252 @default.
- W2414897195 hasConceptScore W2414897195C181199279 @default.
- W2414897195 hasConceptScore W2414897195C185592680 @default.
- W2414897195 hasConceptScore W2414897195C2776350231 @default.
- W2414897195 hasConceptScore W2414897195C2776714187 @default.
- W2414897195 hasConceptScore W2414897195C2777774944 @default.
- W2414897195 hasConceptScore W2414897195C2778775115 @default.
- W2414897195 hasConceptScore W2414897195C28021979 @default.
- W2414897195 hasConceptScore W2414897195C28406088 @default.
- W2414897195 hasConceptScore W2414897195C50476208 @default.
- W2414897195 hasConceptScore W2414897195C55493867 @default.
- W2414897195 hasConceptScore W2414897195C78553746 @default.
- W2414897195 hasConceptScore W2414897195C79879829 @default.
- W2414897195 hasConceptScore W2414897195C86803240 @default.
- W2414897195 hasConceptScore W2414897195C96294017 @default.
- W2414897195 hasIssue "3-4" @default.
- W2414897195 hasLocation W24148971951 @default.
- W2414897195 hasOpenAccess W2414897195 @default.
- W2414897195 hasPrimaryLocation W24148971951 @default.
- W2414897195 hasRelatedWork W1602905293 @default.
- W2414897195 hasRelatedWork W2040648848 @default.
- W2414897195 hasRelatedWork W2060678282 @default.
- W2414897195 hasRelatedWork W2073876416 @default.
- W2414897195 hasRelatedWork W2084862719 @default.
- W2414897195 hasRelatedWork W2092055364 @default.
- W2414897195 hasRelatedWork W2276943216 @default.
- W2414897195 hasRelatedWork W2400504672 @default.
- W2414897195 hasRelatedWork W2414897195 @default.
- W2414897195 hasRelatedWork W78885309 @default.
- W2414897195 hasVolume "35" @default.
- W2414897195 isParatext "false" @default.
- W2414897195 isRetracted "false" @default.
- W2414897195 magId "2414897195" @default.
- W2414897195 workType "article" @default.