FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414920586> ?p ?o ?g. }

• W2414920586 endingPage "4391" @default.
• W2414920586 startingPage "4387" @default.
• W2414920586 abstract "Carboxyl methylation of platelet ras-related proteins, known as rap proteins, was investigated in this study. Platelet membrane proteins of Mr 23,000 incorporated radioactivity in the presence of S-[methyl-3H]adenosylmethionine and platelet cytosol. About 97% of the radioactivity present in the Mr 23,000 proteins was liberated as volatile methanol under basic (1 M sodium hydroxide) conditions. Cycloheximide, an inhibitor of protein synthesis, inhibited incorporation of S-[methyl-3H]adenosylmethionine by 25%. These results suggest that at least 75% of the radioactivity present in the Mr 23,000 proteins is due to carboxyl methylation and not due to the incorporation of S-[methyl-3H]adenosylmethionine into proteins or due to the incorporation of base-stable methyl groups into side chains of arginine, histidine, or lysine residues. Protein methylation did not occur if membranes or cytosol alone was incubated with S-[methyl-3H]adenosylmethionine. Guanosine 5'(3-O-thio)triphosphate increased methylation of the Mr 23,000 proteins in a time- and concentration-dependent manner. Acetyl-farnesylcysteine, a synthetic substrate for carboxyl methyltransferases, completely blocked methylation of the Mr 23,000 membrane proteins. On the basis of one- and two-dimensional Western blots using rap-specific antisera, the Mr 23,000 methylated proteins were identified as rap1 proteins. The existence of the carboxyl-terminal CAAX motif in rap1 proteins, similar to the CAAX motif present in p21ras as well as in the yeast mating factors, leads us to suggest that methylation of rap1 proteins possibly occurs at the alpha-carboxyl-terminal cysteine." @default.
• W2414920586 created "2016-06-24" @default.
• W2414920586 creator A5010453470 @default.
• W2414920586 creator A5030640610 @default.
• W2414920586 creator A5090804771 @default.
• W2414920586 date "1991-03-01" @default.
• W2414920586 modified "2023-09-30" @default.
• W2414920586 title "Carboxyl methylation of platelet rap1 proteins is stimulated by guanosine 5'-(3-O-thio)triphosphate" @default.
• W2414920586 cites W1479350751 @default.
• W2414920586 cites W1484367541 @default.
• W2414920586 cites W1499411585 @default.
• W2414920586 cites W1500314244 @default.
• W2414920586 cites W1503647622 @default.
• W2414920586 cites W1508018835 @default.
• W2414920586 cites W1560820482 @default.
• W2414920586 cites W1561770236 @default.
• W2414920586 cites W1606423922 @default.
• W2414920586 cites W1639281802 @default.
• W2414920586 cites W2003267467 @default.
• W2414920586 cites W2014987538 @default.
• W2414920586 cites W2016470139 @default.
• W2414920586 cites W2020960046 @default.
• W2414920586 cites W2030300468 @default.
• W2414920586 cites W2046323809 @default.
• W2414920586 cites W2068656733 @default.
• W2414920586 cites W207418012 @default.
• W2414920586 cites W2076708431 @default.
• W2414920586 cites W2077788859 @default.
• W2414920586 cites W2078637117 @default.
• W2414920586 cites W2080875376 @default.
• W2414920586 cites W2083529249 @default.
• W2414920586 cites W2090695674 @default.
• W2414920586 cites W2100837269 @default.
• W2414920586 cites W2114891213 @default.
• W2414920586 cites W2133362776 @default.
• W2414920586 cites W2176699929 @default.
• W2414920586 cites W35037724 @default.
• W2414920586 doi "https://doi.org/10.1016/s0021-9258(20)64334-4" @default.
• W2414920586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1900293" @default.
• W2414920586 hasPublicationYear "1991" @default.
• W2414920586 type Work @default.
• W2414920586 sameAs 2414920586 @default.
• W2414920586 citedByCount "36" @default.
• W2414920586 countsByYear W24149205862014 @default.
• W2414920586 crossrefType "journal-article" @default.
• W2414920586 hasAuthorship W2414920586A5010453470 @default.
• W2414920586 hasAuthorship W2414920586A5030640610 @default.
• W2414920586 hasAuthorship W2414920586A5090804771 @default.
• W2414920586 hasBestOaLocation W24149205861 @default.
• W2414920586 hasConcept C104317684 @default.
• W2414920586 hasConcept C185592680 @default.
• W2414920586 hasConcept C203014093 @default.
• W2414920586 hasConcept C2776179587 @default.
• W2414920586 hasConcept C2776638253 @default.
• W2414920586 hasConcept C2777995097 @default.
• W2414920586 hasConcept C2779564974 @default.
• W2414920586 hasConcept C2779817904 @default.
• W2414920586 hasConcept C2781253882 @default.
• W2414920586 hasConcept C33288867 @default.
• W2414920586 hasConcept C512185932 @default.
• W2414920586 hasConcept C552990157 @default.
• W2414920586 hasConcept C55493867 @default.
• W2414920586 hasConcept C71240020 @default.
• W2414920586 hasConcept C86803240 @default.
• W2414920586 hasConcept C89560881 @default.
• W2414920586 hasConceptScore W2414920586C104317684 @default.
• W2414920586 hasConceptScore W2414920586C185592680 @default.
• W2414920586 hasConceptScore W2414920586C203014093 @default.
• W2414920586 hasConceptScore W2414920586C2776179587 @default.
• W2414920586 hasConceptScore W2414920586C2776638253 @default.
• W2414920586 hasConceptScore W2414920586C2777995097 @default.
• W2414920586 hasConceptScore W2414920586C2779564974 @default.
• W2414920586 hasConceptScore W2414920586C2779817904 @default.
• W2414920586 hasConceptScore W2414920586C2781253882 @default.
• W2414920586 hasConceptScore W2414920586C33288867 @default.
• W2414920586 hasConceptScore W2414920586C512185932 @default.
• W2414920586 hasConceptScore W2414920586C552990157 @default.
• W2414920586 hasConceptScore W2414920586C55493867 @default.
• W2414920586 hasConceptScore W2414920586C71240020 @default.
• W2414920586 hasConceptScore W2414920586C86803240 @default.
• W2414920586 hasConceptScore W2414920586C89560881 @default.
• W2414920586 hasIssue "7" @default.
• W2414920586 hasLocation W24149205861 @default.
• W2414920586 hasOpenAccess W2414920586 @default.
• W2414920586 hasPrimaryLocation W24149205861 @default.
• W2414920586 hasRelatedWork W1485780383 @default.
• W2414920586 hasRelatedWork W1502322594 @default.
• W2414920586 hasRelatedWork W1582130281 @default.
• W2414920586 hasRelatedWork W1976891239 @default.
• W2414920586 hasRelatedWork W1999651926 @default.
• W2414920586 hasRelatedWork W2120128263 @default.
• W2414920586 hasRelatedWork W2414300509 @default.
• W2414920586 hasRelatedWork W2613179094 @default.
• W2414920586 hasRelatedWork W4243690135 @default.
• W2414920586 hasRelatedWork W979752654 @default.
• W2414920586 hasVolume "266" @default.
• W2414920586 isParatext "false" @default.
• W2414920586 isRetracted "false" @default.

• next