Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414930168> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2414930168 endingPage "4" @default.
- W2414930168 startingPage "1" @default.
- W2414930168 abstract "The reversibility of inhibition of plasma, red blood cell (RBC), and diaphragm cholinesterase (ChE) and clinical signs in mice given anatoxin-a(s) [antx-a(s)], a ChE inhibitor from Anabaena flos-aquae NRC-525-17, were characterized and compared with the effects of 2 known ChE inhibitors, the organophosphorus compound paraoxon and the carbamate pyridostigmine bromide. To follow recovery of ChE activity, mice were given either a control solution or an LD40 dose of one of the toxicants ip and killed at time points up to 8 d postdosing. After dosing, mice were monitored for diarrhea, fasciculations, respiratory difficulty, salivation, and tremors. In general, clinical signs in mice given antx-a(s) persisted longer than in mice given pyridostigmine and were more similar in duration to the clinical signs in mice given paraoxon. Histologic lesions were not detected in tissues of mice killed after administration of antx-a(s). Anatoxin-a(s) inhibited lesions were diaphragm ChE for greater than 1 but less than 2 d and RBC ChE for 8 d. The time required for recovery from Antx-a(s)-induced inhibition of ChE in plasma, RBC, and diaphragm was similar to or longer than that with paraoxon and longer than that with pyridostigmine. Based on the duration of antx-a(s) induced clinical signs and ChE inhibition in mice, antx-a(s) appears to be an in vivo irreversible inhibitor of ChE." @default.
- W2414930168 created "2016-06-24" @default.
- W2414930168 creator A5012118356 @default.
- W2414930168 creator A5027689278 @default.
- W2414930168 creator A5036993392 @default.
- W2414930168 creator A5052604293 @default.
- W2414930168 creator A5059437012 @default.
- W2414930168 creator A5082892696 @default.
- W2414930168 creator A5088558289 @default.
- W2414930168 date "1991-02-01" @default.
- W2414930168 modified "2023-10-05" @default.
- W2414930168 title "Reversal of cholinesterase inhibition and clinical signs and the postmortem findings in mice after intraperitoneal administration of anatoxin-a(s), paraoxon or pyridostigmine." @default.
- W2414930168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2017858" @default.
- W2414930168 hasPublicationYear "1991" @default.
- W2414930168 type Work @default.
- W2414930168 sameAs 2414930168 @default.
- W2414930168 citedByCount "2" @default.
- W2414930168 countsByYear W24149301682015 @default.
- W2414930168 countsByYear W24149301682017 @default.
- W2414930168 crossrefType "journal-article" @default.
- W2414930168 hasAuthorship W2414930168A5012118356 @default.
- W2414930168 hasAuthorship W2414930168A5027689278 @default.
- W2414930168 hasAuthorship W2414930168A5036993392 @default.
- W2414930168 hasAuthorship W2414930168A5052604293 @default.
- W2414930168 hasAuthorship W2414930168A5059437012 @default.
- W2414930168 hasAuthorship W2414930168A5082892696 @default.
- W2414930168 hasAuthorship W2414930168A5088558289 @default.
- W2414930168 hasConcept C126322002 @default.
- W2414930168 hasConcept C134018914 @default.
- W2414930168 hasConcept C150903083 @default.
- W2414930168 hasConcept C161176658 @default.
- W2414930168 hasConcept C181199279 @default.
- W2414930168 hasConcept C185592680 @default.
- W2414930168 hasConcept C207001950 @default.
- W2414930168 hasConcept C2776588719 @default.
- W2414930168 hasConcept C2777207434 @default.
- W2414930168 hasConcept C2778105408 @default.
- W2414930168 hasConcept C2778816929 @default.
- W2414930168 hasConcept C2778970341 @default.
- W2414930168 hasConcept C2779901103 @default.
- W2414930168 hasConcept C2910532367 @default.
- W2414930168 hasConcept C31896038 @default.
- W2414930168 hasConcept C42219234 @default.
- W2414930168 hasConcept C55493867 @default.
- W2414930168 hasConcept C6557445 @default.
- W2414930168 hasConcept C71924100 @default.
- W2414930168 hasConcept C86803240 @default.
- W2414930168 hasConcept C98274493 @default.
- W2414930168 hasConceptScore W2414930168C126322002 @default.
- W2414930168 hasConceptScore W2414930168C134018914 @default.
- W2414930168 hasConceptScore W2414930168C150903083 @default.
- W2414930168 hasConceptScore W2414930168C161176658 @default.
- W2414930168 hasConceptScore W2414930168C181199279 @default.
- W2414930168 hasConceptScore W2414930168C185592680 @default.
- W2414930168 hasConceptScore W2414930168C207001950 @default.
- W2414930168 hasConceptScore W2414930168C2776588719 @default.
- W2414930168 hasConceptScore W2414930168C2777207434 @default.
- W2414930168 hasConceptScore W2414930168C2778105408 @default.
- W2414930168 hasConceptScore W2414930168C2778816929 @default.
- W2414930168 hasConceptScore W2414930168C2778970341 @default.
- W2414930168 hasConceptScore W2414930168C2779901103 @default.
- W2414930168 hasConceptScore W2414930168C2910532367 @default.
- W2414930168 hasConceptScore W2414930168C31896038 @default.
- W2414930168 hasConceptScore W2414930168C42219234 @default.
- W2414930168 hasConceptScore W2414930168C55493867 @default.
- W2414930168 hasConceptScore W2414930168C6557445 @default.
- W2414930168 hasConceptScore W2414930168C71924100 @default.
- W2414930168 hasConceptScore W2414930168C86803240 @default.
- W2414930168 hasConceptScore W2414930168C98274493 @default.
- W2414930168 hasIssue "1" @default.
- W2414930168 hasLocation W24149301681 @default.
- W2414930168 hasOpenAccess W2414930168 @default.
- W2414930168 hasPrimaryLocation W24149301681 @default.
- W2414930168 hasRelatedWork W1965000068 @default.
- W2414930168 hasRelatedWork W2015447547 @default.
- W2414930168 hasRelatedWork W2089164126 @default.
- W2414930168 hasRelatedWork W2106645926 @default.
- W2414930168 hasRelatedWork W2109781636 @default.
- W2414930168 hasRelatedWork W2141592420 @default.
- W2414930168 hasRelatedWork W2414930168 @default.
- W2414930168 hasRelatedWork W2953808021 @default.
- W2414930168 hasRelatedWork W33154224 @default.
- W2414930168 hasRelatedWork W4250452816 @default.
- W2414930168 hasVolume "33" @default.
- W2414930168 isParatext "false" @default.
- W2414930168 isRetracted "false" @default.
- W2414930168 magId "2414930168" @default.
- W2414930168 workType "article" @default.