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- W2414932518 abstract "To evaluate the role of costimulatory B7 molecules in the pathogenesis of drug induced interstitial nephritis(D-TIN) and IgA nephropathy with severe tubulointerstitial injury(IgAN).Renal biopsy materials from D-TIN(n = 15) and IgAN(n = 15) were used. Cadaveric donors for kidney transplantation(n = 10) served as normal controls. The lymphocyte subsets and the expression of B7-1, B7-2 and HLA-DR in the renal tissue were analyzed by immunohistochemistry staining.CD4+ and CD8+ cells in the interstitium markedly increased in patients with D-TIN. Parallelly, B7-1 and B7-2 expressing cells in the interstitium also augmented in this group of patients. The expression of B7-1 and HLA-DR on the renal tubular cells increased in patients with D-TIN. Although CD4+ and CD8+ cells increased in the interstitium of IgAN, the B7-1 and B7-2 expressing cells in the interstitium were not different from those of the normal controls. Although the renal tubular expression of B7-1 was upregulated in IgAN, the expression of HLA-DR kept in the normal range.These results indicate that the costimulatory molecules mediated T cell activation plays an important role in the pathogenesis of D-TIN. The interstitial infiltrating and tubular cells both act as an antigen presenting cells in the initiation of immune injury in D-TIN. However, such evidence has not been found in patients with IgAN." @default.
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- W2414932518 date "1998-07-01" @default.
- W2414932518 modified "2023-09-27" @default.
- W2414932518 title "[Costimulatory B7 molecules in drug induced interstitial nephritis and IgA nephropathy with tubulointerstitial injury]." @default.
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