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- W2414952944 endingPage "2214" @default.
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- W2414952944 abstract "Glioblastoma multiforme (GBM) is the most common and aggressive primary neoplasm of the brain. Poor prognosis is mainly attributed to tumor heterogeneity, invasiveness, and drug resistance. microRNA-based therapeutics represent a promising approach due to their ability to inhibit multiple targets. In this work, we aim to restore the oncosuppressor activity of microRNA-34a (miR-34a) in GBM. We developed a cationic carrier system, dendritic polyglycerolamine (dPG-NH2), which remarkably improves miRNA stability, intracellular trafficking, and activity. dPG-NH2 carrying mature miR-34a targets C-MET, CDK6, Notch1 and BCL-2, consequently inhibiting cell cycle progression, proliferation and migration of GBM cells. Following complexation with dPG-NH2, miRNA is stable in plasma and able to cross the blood-brain barrier. We further show inhibition of tumor growth following treatment with dPG-NH2-miR-34a in a human glioblastoma mouse model. We hereby present a promising technology using dPG-NH2-miR-34a polyplex for brain-tumor treatment, with enhanced efficacy and no apparent signs of toxicity." @default.
- W2414952944 created "2016-06-24" @default.
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- W2414952944 date "2016-10-01" @default.
- W2414952944 modified "2023-09-26" @default.
- W2414952944 title "Restoring the oncosuppressor activity of microRNA-34a in glioblastoma using a polyglycerol-based polyplex" @default.
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- W2414952944 doi "https://doi.org/10.1016/j.nano.2016.05.016" @default.
- W2414952944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5364374" @default.
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- W2414952944 hasPublicationYear "2016" @default.
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