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- W2414953608 endingPage "378" @default.
- W2414953608 startingPage "353" @default.
- W2414953608 abstract "Store Operated Ca2+ Entry (SOCE), the main Ca2+ influx mechanism in non-excitable cells, is implicated in the immune response and has been reported to be affected in several pathologies including cancer. The basic molecular constituents of SOCE are Orai, the pore forming unit, and STIM, a multidomain protein with at least two principal functions: one is to sense the Ca2+ content inside the lumen of the endoplasmic reticulum(ER) and the second is to activate Orai channels upon depletion of the ER. The link between Ca2+ depletion inside the ER and Ca2+ influx from extracellular media is through a direct association of STIM and Orai, but for this to occur, both molecules have to interact and form clusters where ER and plasma membrane (PM) are intimately apposed. In recent years a great number of components have been identified as participants in SOCE regulation, including regions of plasma membrane enriched in cholesterol and sphingolipids, the so called lipid rafts, which recruit a complex platform of specialized microdomains, which cells use to regulate spatiotemporal Ca2+ signals." @default.
- W2414953608 created "2016-06-24" @default.
- W2414953608 creator A5010320035 @default.
- W2414953608 creator A5035304780 @default.
- W2414953608 creator A5048083035 @default.
- W2414953608 date "2016-01-01" @default.
- W2414953608 modified "2023-10-01" @default.
- W2414953608 title "Microdomains Associated to Lipid Rafts" @default.
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