Matches in SemOpenAlex for { <https://semopenalex.org/work/W2414955812> ?p ?o ?g. }
- W2414955812 endingPage "127" @default.
- W2414955812 startingPage "97" @default.
- W2414955812 abstract "Base- and sugar-modified analogs of DNA and RNA are finding ever expanding use in medicine and biotechnology as tools to better tailor structured oligonucleotides by altering their thermal stability, nuclease resistance, base-pairing specificity, antisense activity, or cellular uptake. Proper deployment of these chemical modifications generally requires knowledge of how each affects base-pairing properties and thermal stabilities. Here, we describe in detail how differential scanning calorimetry and UV spectroscopy may be used to quantify the melting thermodynamics of short dsDNA containing chemically modified nucleosides in one or both strands. Insights are provided into why and how the presence of highly stable base pairs containing modified nucleosides can alter the nature of calorimetry or melting spectroscopy data, and how each experiment must therefore be conducted to ensure high-quality melting thermodynamics data are obtained. Strengths and weaknesses of the two methods when applied to chemically modified duplexes are also addressed." @default.
- W2414955812 created "2016-06-24" @default.
- W2414955812 creator A5003258986 @default.
- W2414955812 creator A5033096428 @default.
- W2414955812 creator A5045148086 @default.
- W2414955812 creator A5088537302 @default.
- W2414955812 creator A5090580978 @default.
- W2414955812 date "2016-01-01" @default.
- W2414955812 modified "2023-09-25" @default.
- W2414955812 title "Calorimetric and Spectroscopic Analysis of the Thermal Stability of Short Duplex DNA-Containing Sugar and Base-Modified Nucleotides" @default.
- W2414955812 cites W1498040952 @default.
- W2414955812 cites W1517927116 @default.
- W2414955812 cites W1970663985 @default.
- W2414955812 cites W1971377724 @default.
- W2414955812 cites W1983297903 @default.
- W2414955812 cites W1985443686 @default.
- W2414955812 cites W1985776657 @default.
- W2414955812 cites W1994871130 @default.
- W2414955812 cites W1994923998 @default.
- W2414955812 cites W1998666145 @default.
- W2414955812 cites W2000515579 @default.
- W2414955812 cites W2009095852 @default.
- W2414955812 cites W2010759469 @default.
- W2414955812 cites W2025276261 @default.
- W2414955812 cites W2025916571 @default.
- W2414955812 cites W2054423031 @default.
- W2414955812 cites W2066461480 @default.
- W2414955812 cites W2067113086 @default.
- W2414955812 cites W2073719188 @default.
- W2414955812 cites W2073880037 @default.
- W2414955812 cites W2073938250 @default.
- W2414955812 cites W2074328423 @default.
- W2414955812 cites W2077104455 @default.
- W2414955812 cites W2080044949 @default.
- W2414955812 cites W2082280007 @default.
- W2414955812 cites W2084798836 @default.
- W2414955812 cites W2086452686 @default.
- W2414955812 cites W2089927103 @default.
- W2414955812 cites W2090221464 @default.
- W2414955812 cites W2091559790 @default.
- W2414955812 cites W2091911940 @default.
- W2414955812 cites W2104694288 @default.
- W2414955812 cites W2108700458 @default.
- W2414955812 cites W2109887615 @default.
- W2414955812 cites W2110975678 @default.
- W2414955812 cites W2114163010 @default.
- W2414955812 cites W2116079511 @default.
- W2414955812 cites W2118109579 @default.
- W2414955812 cites W2124235959 @default.
- W2414955812 cites W2126963444 @default.
- W2414955812 cites W2135995702 @default.
- W2414955812 cites W2138258050 @default.
- W2414955812 cites W2146400725 @default.
- W2414955812 cites W2149343488 @default.
- W2414955812 cites W2152093192 @default.
- W2414955812 cites W2158347183 @default.
- W2414955812 cites W2165445035 @default.
- W2414955812 cites W2312751351 @default.
- W2414955812 cites W2321572025 @default.
- W2414955812 cites W2328535333 @default.
- W2414955812 cites W2333435735 @default.
- W2414955812 doi "https://doi.org/10.1016/bs.mie.2015.08.001" @default.
- W2414955812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26794352" @default.
- W2414955812 hasPublicationYear "2016" @default.
- W2414955812 type Work @default.
- W2414955812 sameAs 2414955812 @default.
- W2414955812 citedByCount "1" @default.
- W2414955812 countsByYear W24149558122021 @default.
- W2414955812 crossrefType "book-chapter" @default.
- W2414955812 hasAuthorship W2414955812A5003258986 @default.
- W2414955812 hasAuthorship W2414955812A5033096428 @default.
- W2414955812 hasAuthorship W2414955812A5045148086 @default.
- W2414955812 hasAuthorship W2414955812A5088537302 @default.
- W2414955812 hasAuthorship W2414955812A5090580978 @default.
- W2414955812 hasConcept C104317684 @default.
- W2414955812 hasConcept C121332964 @default.
- W2414955812 hasConcept C129312508 @default.
- W2414955812 hasConcept C134306372 @default.
- W2414955812 hasConcept C178790620 @default.
- W2414955812 hasConcept C185581394 @default.
- W2414955812 hasConcept C185592680 @default.
- W2414955812 hasConcept C186399102 @default.
- W2414955812 hasConcept C21951064 @default.
- W2414955812 hasConcept C2777132085 @default.
- W2414955812 hasConcept C2780535078 @default.
- W2414955812 hasConcept C33923547 @default.
- W2414955812 hasConcept C39519442 @default.
- W2414955812 hasConcept C42058472 @default.
- W2414955812 hasConcept C512185932 @default.
- W2414955812 hasConcept C552990157 @default.
- W2414955812 hasConcept C55493867 @default.
- W2414955812 hasConcept C59061564 @default.
- W2414955812 hasConcept C97355855 @default.
- W2414955812 hasConcept C99611785 @default.
- W2414955812 hasConceptScore W2414955812C104317684 @default.
- W2414955812 hasConceptScore W2414955812C121332964 @default.
- W2414955812 hasConceptScore W2414955812C129312508 @default.
- W2414955812 hasConceptScore W2414955812C134306372 @default.