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- W2414970045 abstract "Abstract A continuing enigma in the study of biological systems is what happens to highly ordered structures, far from equilibrium, when their regulatory systems suddenly become disabled. In life, genetic and epigenetic networks precisely coordinate the expression of genes -- but in death, it is not known if gene expression diminishes gradually or abruptly stops or if specific genes are involved. We investigated the unwinding of the clock by identifying upregulated genes, assessing their functions, and comparing their transcriptional profiles through postmortem time in two species, mouse and zebrafish. We found transcriptional abundance profiles of 1,063 genes were significantly changed after death of healthy adult animals in a time series spanning from life to 48 or 96 h postmortem. Ordination plots revealed non-random patterns in profiles by time. While most thanatotranscriptome (thanatos-, Greek defn . death) transcript levels increased within 0.5 h postmortem, some increased only at 24 and 48 h. Functional characterization of the most abundant transcripts revealed the following categories: stress, immunity, inflammation, apoptosis, transport, development, epigenetic regulation, and cancer. The increase of transcript abundance was presumably due to thermodynamic and kinetic controls encountered such as the activation of epigenetic modification genes responsible for unraveling the nucleosomes, which enabled transcription of previously silenced genes (e.g., development genes). The fact that new molecules were synthesized at 48 to 96 h postmortem suggests sufficient energy and resources to maintain self-organizing processes. A step-wise shutdown occurs in organismal death that is manifested by the apparent upregulation of genes with various abundance maxima and durations. The results are of significance to transplantology and molecular biology." @default.
- W2414970045 created "2016-06-24" @default.
- W2414970045 creator A5005942244 @default.
- W2414970045 creator A5018355185 @default.
- W2414970045 creator A5025057823 @default.
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- W2414970045 creator A5040718895 @default.
- W2414970045 creator A5044012953 @default.
- W2414970045 creator A5068232426 @default.
- W2414970045 date "2016-06-10" @default.
- W2414970045 modified "2023-10-14" @default.
- W2414970045 title "Thanatotranscriptome: genes actively expressed after organismal death" @default.
- W2414970045 cites W1151817657 @default.
- W2414970045 cites W134271320 @default.
- W2414970045 cites W1510958293 @default.
- W2414970045 cites W1522763255 @default.
- W2414970045 cites W154312111 @default.
- W2414970045 cites W1550642465 @default.
- W2414970045 cites W1556397195 @default.
- W2414970045 cites W1572525448 @default.
- W2414970045 cites W1574669505 @default.
- W2414970045 cites W1575559361 @default.
- W2414970045 cites W1591222350 @default.
- W2414970045 cites W1594557237 @default.
- W2414970045 cites W1596172840 @default.
- W2414970045 cites W1657823335 @default.
- W2414970045 cites W1754742998 @default.
- W2414970045 cites W1790565217 @default.
- W2414970045 cites W1824742098 @default.
- W2414970045 cites W1826874877 @default.
- W2414970045 cites W1858171089 @default.
- W2414970045 cites W1860483473 @default.
- W2414970045 cites W1896223061 @default.
- W2414970045 cites W1945945498 @default.
- W2414970045 cites W1962453948 @default.
- W2414970045 cites W1964076699 @default.
- W2414970045 cites W1964249139 @default.
- W2414970045 cites W1964508452 @default.
- W2414970045 cites W1965916060 @default.
- W2414970045 cites W1966216178 @default.
- W2414970045 cites W1966452335 @default.
- W2414970045 cites W1967064280 @default.
- W2414970045 cites W1968429206 @default.
- W2414970045 cites W1968679998 @default.
- W2414970045 cites W1969771743 @default.
- W2414970045 cites W1969784842 @default.
- W2414970045 cites W1971907885 @default.
- W2414970045 cites W1973617256 @default.
- W2414970045 cites W1973769556 @default.
- W2414970045 cites W1975343234 @default.
- W2414970045 cites W1975556592 @default.
- W2414970045 cites W1979719368 @default.
- W2414970045 cites W1982157071 @default.
- W2414970045 cites W1983295913 @default.
- W2414970045 cites W1983983875 @default.
- W2414970045 cites W1984711192 @default.
- W2414970045 cites W1987861824 @default.
- W2414970045 cites W1987975569 @default.
- W2414970045 cites W1988521127 @default.
- W2414970045 cites W1992242907 @default.
- W2414970045 cites W1995566485 @default.
- W2414970045 cites W1997135806 @default.
- W2414970045 cites W1998289083 @default.
- W2414970045 cites W2000319686 @default.
- W2414970045 cites W2001760728 @default.
- W2414970045 cites W2002414447 @default.
- W2414970045 cites W2002588250 @default.
- W2414970045 cites W2003567202 @default.
- W2414970045 cites W2008555978 @default.
- W2414970045 cites W2010233116 @default.
- W2414970045 cites W2012063163 @default.
- W2414970045 cites W2014108329 @default.
- W2414970045 cites W2015157276 @default.
- W2414970045 cites W2017102177 @default.
- W2414970045 cites W2019083595 @default.
- W2414970045 cites W2019678439 @default.
- W2414970045 cites W2020820462 @default.
- W2414970045 cites W2020941408 @default.
- W2414970045 cites W2021262975 @default.
- W2414970045 cites W2026292446 @default.
- W2414970045 cites W2026576443 @default.
- W2414970045 cites W2027997188 @default.
- W2414970045 cites W20280261 @default.
- W2414970045 cites W2032619610 @default.
- W2414970045 cites W2033396645 @default.
- W2414970045 cites W2033543553 @default.
- W2414970045 cites W2036020241 @default.
- W2414970045 cites W2036109696 @default.
- W2414970045 cites W2038610464 @default.
- W2414970045 cites W2039051124 @default.
- W2414970045 cites W2039340205 @default.
- W2414970045 cites W2039854830 @default.
- W2414970045 cites W2040141159 @default.
- W2414970045 cites W2040546415 @default.
- W2414970045 cites W2042048325 @default.
- W2414970045 cites W2042223610 @default.
- W2414970045 cites W2042359860 @default.
- W2414970045 cites W2042717737 @default.
- W2414970045 cites W2042851093 @default.
- W2414970045 cites W2043978867 @default.