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- W2414974527 abstract "ABSTRACT Cytoplasmic pH (pH1) was measured by a pH ‘null point’ method in synchronous populations of Dictyostelium discoideum cells. Synchronous populations of vegetative cells with a lower pH1 than asynchronous populations of vegetative cells show a clear preference for the prespore differentiation pathway when they enter development. Treatment of these cells before development with the weak base ammonia results in an increase in pH1 and an abolition of the preference of the cells for the prespore pathway. On the other hand, synchronous populations of vegetative cells with the same pH) as asynchronous populations of vegetative cells resemble these last cells in that they show no preference for a certain differentiation direction when they enter development. However, both these synchronous and asynchronous populations of cells do acquire a preference for the prespore pathway when they are treated before development with the weak acid 5,5-dimethyl-2,4-oxazolidineolione (DMO), which lowers their pH). It is concluded that changes in pH1 at the onset of the developmental program lead to significant changes in the preference of the cells for the prespore differentiation pathway in Dictyostelium discoideum." @default.
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- W2414974527 date "1987-04-01" @default.
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- W2414974527 title "Cytoplasmic ph at the onset of development in <i>Dictyostelium</i>" @default.
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- W2414974527 doi "https://doi.org/10.1242/jcs.87.3.423" @default.
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