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- W2414979319 abstract "The anti-isoprenaline and negative inotropic activity in the electrically stimulated guinea-pig left atria as well as the local anaesthetic activity of three 4-(2-hydroxy-3-isopropyl-aminopropoxy)-3-(alkoxymethyl) acetophenone derivatives were evaluated. The efficiency of the compounds was compared with the beta-adrenolytic drug atenolol. All of the compounds tested exhibited a statistically significant anti-isoprenaline activity, which increased from the propoxy- to heptyloxyderivative. However, the nonspecific cardiodepressive and local anaesthetic effects of the drugs increased in the same order: propoxy- < pentyloxy- < heptyloxyderivative." @default.
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- W2414979319 date "1994-07-01" @default.
- W2414979319 modified "2023-10-18" @default.
- W2414979319 title "[Pharmacologic evaluation of p-hydroxyacetophenone derivatives as potential beta-adrenolytics]." @default.
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