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• W2414994807 abstract "Ewing sarcoma (EWS) is a malignant tumour of bone and soft tissue, and although many patients are cured with conventional multimodal therapy, those with recurrent or metastatic disease have a poor prognosis. Genomic instability and programmed cell death ligand-1 (PD-L1) expression have been identified in EWS, providing a rationale for treatment with agents that block the programmed cell death-1 (PD-1) receptor.In this report, we describe a heavily pre-treated patient with recurrent metastatic EWS who achieved a clinical and radiological remission with PD-1 blockade.To our knowledge, this is the first reported case demonstrating efficacy of PD-1 blockade in EWS. This warrants further investigation in particular given the poor prognosis in patients with recurrent or metastatic disease." @default.
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• W2414994807 date "2016-06-03" @default.
• W2414994807 modified "2023-10-16" @default.
• W2414994807 title "Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma" @default.
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• W2414994807 doi "https://doi.org/10.1186/s13045-016-0278-x" @default.
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