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- W2415004826 abstract "Objective To investigate the effect of Polygonum bistorta L.n-butyl alcohol(PBNA)extract on the NO content and NOS activity in ischemia/reperfusion(I/R)injury in the rat retina.Methods The rats were randomly divided into four groups:control group,retinal I/R injury group,low-dosage PBNA treated group and high-dosage treated PBNA group.The control group was injected with 1 ml·kg-1 NS through sublingual vein after CCA was dissociated.Other groups were treated with normal saline or PBNA before occlusion of CCA.After occlusion of CCA for 1 hour following reperfusion for 1 hour,electroretinogram(ERG)was surveyed,and serum was separated to determine the content of NO,the activities of T-NOS,iNOS and eNOS.Results(1)The amplitude of ERG in I/R group showed lower values than that in control group(P0.01)and two dosage PBNA treated groups(P0.001).(2)The amplitude of ERG and content of NO in I/R group showed lower values than those in control group(P0.001)and low-dosage PBNA treated group(P0.05).(3)The activities of T-NOS in both low-dosage PBNA group and high-dosage group were increased,compared with I/R group(P0.01).(4)The activity of serum iNOS in I/R group was incerased compared with control group(P0.05)and low-dosage PBNA treated group evidently(P0.05).(5)The activity of serum eNOS in I/R group was decreased compared with control group(P0.05),both low-dosage(P0.05)and high-dosage PBNA(P0.01)treated groups markedly.Conclusion PBNA has therapeutic effect on retinal ischemia/reperfusion injury by increasing the activities of T-NOS and eNOS,decreasing the activity of iNOS,elevating the content of NO,enhancing the anti-oxidation and dilating the blood vessel." @default.
- W2415004826 created "2016-06-24" @default.
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- W2415004826 date "2010-01-01" @default.
- W2415004826 modified "2023-09-22" @default.
- W2415004826 title "Effect of PBNA on the NO Content and NOS Activity in Ischemia/Reperfusion Injury in the Rat Retina" @default.
- W2415004826 hasPublicationYear "2010" @default.
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