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• W2415007619 abstract "Abstract Cardiac healing after myocardial ischemia is a complex biological process. Advances in understanding of wound healing response have paved the way for clinical testing of novel molecular imaging to improve clinical outcomes. A key factor for assessing myocardial viability after ischemic injury is the evaluation of angiogenesis accompanying increased expression of integrin α v β 3 . Here, we describe the capability of an α v β 3 integrin-targeting SPECT agent, 99m Tc-IDA-D-[c(RGDfK)] 2 , for identification of ischemic but viable myocardium, i.e., hibernating myocardium which is crucial to predict functional recovery after revascularization, the standard care of cardiovascular medicine. In vivo SPECT imaging of rat models with transient coronary occlusion showed significantly high uptake of 99m Tc-IDA-D-[c(RGDfK)] 2 in the ischemic region. Comparative measurements with 201 Tl SPECT and 18 F-FDG PET, then, proved that such prominent uptake of 99m Tc-IDA-D-[c(RGDfK)] 2 exactly matched the hallmark of hibernation, i.e., the perfusion-metabolism mismatch pattern. The uptake of 99m Tc-IDA-D-[c(RGDfK)] 2 was non-inferior to that of 18 F-FDG, confirmed by time-course variation analysis. Immunohistochemical characterization revealed that an intense signal of 99m Tc-IDA-D-[c(RGDfK)] 2 corresponded to the vibrant angiogenic events with elevated expression of α v β 3 integrin. Together, these results establish that 99m Tc-IDA-D-[c(RGDfK)] 2 SPECT can serve as a sensitive clinical measure for myocardial salvage to identify the patients who might benefit most from revascularization." @default.
• W2415007619 created "2016-06-24" @default.
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• W2415007619 date "2016-06-10" @default.
• W2415007619 modified "2023-10-17" @default.
• W2415007619 title "Identification of Angiogenesis Rich-Viable Myocardium using RGD Dimer based SPECT after Myocardial Infarction" @default.
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• W2415007619 doi "https://doi.org/10.1038/srep27520" @default.
• W2415007619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4901298" @default.
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