FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415030461> ?p ?o ?g. }

• W2415030461 abstract "RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-species. The stability of strains within the quasi-species lies on mutations that are positively selected which in turn depend on whether these mutations are beneficial in either or both hosts. Coevolution of amino acids (aa) is one phenomenon that leads to establishment of favorable traits in viruses and leading to their fitness. Fourteen CHIKV clinical samples collected over three years were subjected to RT-PCR, the four non-structural genes amplified and subjected to various genetic analyses. Coevolution analysis showed 30 aa pairs coevolving in nsP1, 23 aa pairs coevolving in nsP2, 239 in nsP3 and 46 aa coevolving pairs in nsP4 when each non-structural protein was considered independently. Further analysis showed that 705 amino acids pairs of the non-structural polyproteins coevolved together with a correlation coefficient of ≥0.5. Functional relevance of these coevolving amino acids in all the nonstructural proteins of CHIKV were predicted using Eukaryotic Linear Motifs (ELMs) of human. The present study was undertaken to study co-evolving amino acids in the non-structural proteins of chikungunya virus (CHIKV), an important arbovirus. It was observed that several amino acids residues were coevolving and shared common functions." @default.
• W2415030461 created "2016-06-24" @default.
• W2415030461 creator A5006294703 @default.
• W2415030461 creator A5007261817 @default.
• W2415030461 creator A5040536806 @default.
• W2415030461 creator A5052932609 @default.
• W2415030461 creator A5076505521 @default.
• W2415030461 date "2016-06-02" @default.
• W2415030461 modified "2023-10-03" @default.
• W2415030461 title "Analysis of coevolution in nonstructural proteins of chikungunya virus" @default.
• W2415030461 cites W1520533428 @default.
• W2415030461 cites W1963646848 @default.
• W2415030461 cites W1983304589 @default.
• W2415030461 cites W1984012038 @default.
• W2415030461 cites W1984399867 @default.
• W2415030461 cites W2017519756 @default.
• W2415030461 cites W2018915304 @default.
• W2415030461 cites W2022359528 @default.
• W2415030461 cites W2028209843 @default.
• W2415030461 cites W2033869585 @default.
• W2415030461 cites W2040942754 @default.
• W2415030461 cites W2042449228 @default.
• W2415030461 cites W2042795084 @default.
• W2415030461 cites W2043047561 @default.
• W2415030461 cites W2049285992 @default.
• W2415030461 cites W2065921821 @default.
• W2415030461 cites W2067911388 @default.
• W2415030461 cites W2075096317 @default.
• W2415030461 cites W2079635715 @default.
• W2415030461 cites W2087854601 @default.
• W2415030461 cites W2097587716 @default.
• W2415030461 cites W2100069280 @default.
• W2415030461 cites W2103396486 @default.
• W2415030461 cites W2108486693 @default.
• W2415030461 cites W2131943433 @default.
• W2415030461 cites W2140784970 @default.
• W2415030461 cites W2146216458 @default.
• W2415030461 cites W2152207030 @default.
• W2415030461 cites W2155158959 @default.
• W2415030461 cites W2159093669 @default.
• W2415030461 cites W2159675211 @default.
• W2415030461 cites W2160261481 @default.
• W2415030461 cites W2171201196 @default.
• W2415030461 cites W2206815873 @default.
• W2415030461 doi "https://doi.org/10.1186/s12985-016-0543-1" @default.
• W2415030461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4890524" @default.
• W2415030461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27251040" @default.
• W2415030461 hasPublicationYear "2016" @default.
• W2415030461 type Work @default.
• W2415030461 sameAs 2415030461 @default.
• W2415030461 citedByCount "9" @default.
• W2415030461 countsByYear W24150304612017 @default.
• W2415030461 countsByYear W24150304612020 @default.
• W2415030461 countsByYear W24150304612021 @default.
• W2415030461 countsByYear W24150304612022 @default.
• W2415030461 countsByYear W24150304612023 @default.
• W2415030461 crossrefType "journal-article" @default.
• W2415030461 hasAuthorship W2415030461A5006294703 @default.
• W2415030461 hasAuthorship W2415030461A5007261817 @default.
• W2415030461 hasAuthorship W2415030461A5040536806 @default.
• W2415030461 hasAuthorship W2415030461A5052932609 @default.
• W2415030461 hasAuthorship W2415030461A5076505521 @default.
• W2415030461 hasBestOaLocation W24150304611 @default.
• W2415030461 hasConcept C104317684 @default.
• W2415030461 hasConcept C144024400 @default.
• W2415030461 hasConcept C149923435 @default.
• W2415030461 hasConcept C159047783 @default.
• W2415030461 hasConcept C2522874641 @default.
• W2415030461 hasConcept C2781273456 @default.
• W2415030461 hasConcept C2908647359 @default.
• W2415030461 hasConcept C2910895815 @default.
• W2415030461 hasConcept C33009525 @default.
• W2415030461 hasConcept C515207424 @default.
• W2415030461 hasConcept C54355233 @default.
• W2415030461 hasConcept C67705224 @default.
• W2415030461 hasConcept C78458016 @default.
• W2415030461 hasConcept C86803240 @default.
• W2415030461 hasConcept C8769409 @default.
• W2415030461 hasConceptScore W2415030461C104317684 @default.
• W2415030461 hasConceptScore W2415030461C144024400 @default.
• W2415030461 hasConceptScore W2415030461C149923435 @default.
• W2415030461 hasConceptScore W2415030461C159047783 @default.
• W2415030461 hasConceptScore W2415030461C2522874641 @default.
• W2415030461 hasConceptScore W2415030461C2781273456 @default.
• W2415030461 hasConceptScore W2415030461C2908647359 @default.
• W2415030461 hasConceptScore W2415030461C2910895815 @default.
• W2415030461 hasConceptScore W2415030461C33009525 @default.
• W2415030461 hasConceptScore W2415030461C515207424 @default.
• W2415030461 hasConceptScore W2415030461C54355233 @default.
• W2415030461 hasConceptScore W2415030461C67705224 @default.
• W2415030461 hasConceptScore W2415030461C78458016 @default.
• W2415030461 hasConceptScore W2415030461C86803240 @default.
• W2415030461 hasConceptScore W2415030461C8769409 @default.
• W2415030461 hasFunder F4320320717 @default.
• W2415030461 hasIssue "1" @default.
• W2415030461 hasLocation W24150304611 @default.
• W2415030461 hasLocation W24150304612 @default.
• W2415030461 hasLocation W24150304613 @default.
• W2415030461 hasLocation W24150304614 @default.
• W2415030461 hasOpenAccess W2415030461 @default.

• next