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- W2415036617 abstract "Uncoupling the protein-protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an allosteric CRMP2-derived peptide (CBD3) is antinociceptive in rodent models of inflammatory and neuropathic pain. We investigated the efficacy, duration of action, abuse potential, and neurobehavioral toxicity of an improved mutant CRMP2 peptide. A homopolyarginine (R9)-conjugated CBD3-A6K (R9-CBD3-A6K) peptide inhibited the CaV2.2-CRMP2 interaction in a concentration-dependent fashion and diminished surface expression of CaV2.2 and depolarization-evoked Ca influx in rat dorsal root ganglia neurons. In vitro studies demonstrated suppression of excitability of small-to-medium diameter dorsal root ganglion and inhibition of subtypes of voltage-gated Ca channels. Sprague-Dawley rats with tibial nerve injury had profound and long-lasting tactile allodynia and ongoing pain. Immediate administration of R9-CBD3-A6K produced enhanced dopamine release from the nucleus accumbens shell selectively in injured animals, consistent with relief of ongoing pain. R9-CBD3-A6K, when administered repeatedly into the central nervous system ventricles of naive rats, did not result in a positive conditioned place preference demonstrating a lack of abusive liability. Continuous subcutaneous infusion of R9-CBD3-A6K over a 24- to 72-hour period reversed tactile allodynia and ongoing pain, demonstrating a lack of tolerance over this time course. Importantly, continuous infusion of R9-CBD3-A6K did not affect motor activity, anxiety, depression, or memory and learning. Collectively, these results validate the potential therapeutic significance of targeting the CaV-CRMP2 axis for treatment of neuropathic pain." @default.
- W2415036617 created "2016-06-24" @default.
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- W2415036617 date "2016-05-28" @default.
- W2415036617 modified "2023-10-14" @default.
- W2415036617 title "Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential" @default.
- W2415036617 cites W1424802244 @default.
- W2415036617 cites W1491978248 @default.
- W2415036617 cites W1500623595 @default.
- W2415036617 cites W1656615286 @default.
- W2415036617 cites W1965547314 @default.
- W2415036617 cites W1968114963 @default.
- W2415036617 cites W1968770896 @default.
- W2415036617 cites W1974057366 @default.
- W2415036617 cites W1976408536 @default.
- W2415036617 cites W1980775434 @default.
- W2415036617 cites W1981337008 @default.
- W2415036617 cites W1982326881 @default.
- W2415036617 cites W1982551903 @default.
- W2415036617 cites W1983058725 @default.
- W2415036617 cites W1984596133 @default.
- W2415036617 cites W1985021707 @default.
- W2415036617 cites W198742996 @default.
- W2415036617 cites W1989023855 @default.
- W2415036617 cites W1989148923 @default.
- W2415036617 cites W1989768699 @default.
- W2415036617 cites W1990327207 @default.
- W2415036617 cites W2003931218 @default.
- W2415036617 cites W2003966687 @default.
- W2415036617 cites W2005733093 @default.
- W2415036617 cites W2017732628 @default.
- W2415036617 cites W2018062375 @default.
- W2415036617 cites W2019358019 @default.
- W2415036617 cites W2020345477 @default.
- W2415036617 cites W2023647922 @default.
- W2415036617 cites W2030034009 @default.
- W2415036617 cites W2035518576 @default.
- W2415036617 cites W2037111632 @default.
- W2415036617 cites W2037872375 @default.
- W2415036617 cites W2038531512 @default.
- W2415036617 cites W2044860425 @default.
- W2415036617 cites W2046786652 @default.
- W2415036617 cites W2047403290 @default.
- W2415036617 cites W2048793794 @default.
- W2415036617 cites W2049054143 @default.
- W2415036617 cites W2049069390 @default.
- W2415036617 cites W2052380247 @default.
- W2415036617 cites W2053193214 @default.
- W2415036617 cites W2054245055 @default.
- W2415036617 cites W2054442714 @default.
- W2415036617 cites W2054666942 @default.
- W2415036617 cites W2055098706 @default.
- W2415036617 cites W2057199764 @default.
- W2415036617 cites W2057742998 @default.
- W2415036617 cites W2058713207 @default.
- W2415036617 cites W2058985499 @default.
- W2415036617 cites W2059250038 @default.
- W2415036617 cites W2065435424 @default.
- W2415036617 cites W2065685204 @default.
- W2415036617 cites W2069268149 @default.
- W2415036617 cites W2070064761 @default.
- W2415036617 cites W2073702198 @default.
- W2415036617 cites W2078195259 @default.
- W2415036617 cites W2078246592 @default.
- W2415036617 cites W2079902542 @default.
- W2415036617 cites W2080940623 @default.
- W2415036617 cites W2082338288 @default.
- W2415036617 cites W2085599856 @default.
- W2415036617 cites W2088870956 @default.
- W2415036617 cites W2094754857 @default.
- W2415036617 cites W2104450799 @default.
- W2415036617 cites W2109293109 @default.
- W2415036617 cites W2111178305 @default.
- W2415036617 cites W2117954460 @default.
- W2415036617 cites W2123650819 @default.
- W2415036617 cites W2135923112 @default.
- W2415036617 cites W2136130440 @default.
- W2415036617 cites W2137606173 @default.
- W2415036617 cites W2138015077 @default.
- W2415036617 cites W2141778251 @default.
- W2415036617 cites W2142213531 @default.
- W2415036617 cites W2142844399 @default.