FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415070513> ?p ?o ?g. }

• W2415070513 abstract "Introduction There is increasing concern about Mycoplasma genitalium as a cause of urethritis, cervicitis, PID, infertility and ectopic pregnancy. Currently there is no licensed test specific for M. genitalium in the UK, where urethral smear microscopy is recommended in GUM clinics, for symptomatic men only. NAATs testing has been advocated, particularly to detect asymptomatic infection. However, M. genitalium ’s natural history is poorly-understood, making the impact and cost-effectiveness of screening unclear. Methods We used a transmission-dynamic model to synthesise evidence from epidemiological and behavioural studies, and surveillance data for Non-Chlamydial, Non-Gonococcal Urethritis (NCNGU), to better-understand the natural history of M. genitalium . The model is stratified by sex, and incorporates heterogeneous sexual behaviour, symptomatic and asymptomatic infection; PID; care-seeking due to symptoms and routine screening; and treatment failure. We fitted to national surveillance data, (allowing for uncertainty in studies measuring the amount of NCNGU caused by M. genitalium ). We examined the effects of implementing NAAT testing for both sexes in GUM and GP settings. Results Introducing NAAT testing for all men (asymptomatic and symptomatic, in GPs and GUM) detects much more infection in men and treatment reduces transmission to women, whilst testing of women reduces prevalence in women and incidence in men. Introducing NAAT testing for both sexes reduces cumulative PID incidence over 20 years by 13.1%(IQR:9.6%–18.3%). However, there is important uncertainty in M. genitalium ’s natural history parameters, leading to uncertainty in the absolute reduction in PID and other sequelae. Particularly important are the proportion of infections that are symptomatic in men and women; duration of untreated infection; and incidence of PID, infertility and ectopic pregnancy attributable to M. genitalium . Conclusion Further empirical work is required to improve understanding of the key aspects of M. genitalium ’s natural history which we have identified before it will be possible to determine if screening is cost-effective. Disclosure of interest statement This presentation reports independent research commissioned by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (RP-PG-0707–10208). In addition, PJW thanks the UK Medical Research Council for Centre funding (grant MR/K010174/1) and also thanks the UK National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Modelling Methodology at Imperial College London in partnership with Public Health England (PHE) for funding (grant HPRU-2012–10080). The views expressed in this paper are those of the authors and not necessarily those of the NHS, the NIHR, the Department of Health, or Public Health England. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We have no conflicts of interest." @default.
• W2415070513 created "2016-06-24" @default.
• W2415070513 creator A5016598310 @default.
• W2415070513 creator A5039239662 @default.
• W2415070513 creator A5049806282 @default.
• W2415070513 creator A5060052660 @default.
• W2415070513 creator A5075245766 @default.
• W2415070513 creator A5082128107 @default.
• W2415070513 creator A5083380890 @default.
• W2415070513 date "2015-09-01" @default.
• W2415070513 modified "2023-10-07" @default.
• W2415070513 title "P09.11 Should we screen formycoplasma genitalium? evidence synthesis using a transmission-dynamic model" @default.
• W2415070513 doi "https://doi.org/10.1136/sextrans-2015-052270.395" @default.
• W2415070513 hasPublicationYear "2015" @default.
• W2415070513 type Work @default.
• W2415070513 sameAs 2415070513 @default.
• W2415070513 citedByCount "0" @default.
• W2415070513 crossrefType "journal-article" @default.
• W2415070513 hasAuthorship W2415070513A5016598310 @default.
• W2415070513 hasAuthorship W2415070513A5039239662 @default.
• W2415070513 hasAuthorship W2415070513A5049806282 @default.
• W2415070513 hasAuthorship W2415070513A5060052660 @default.
• W2415070513 hasAuthorship W2415070513A5075245766 @default.
• W2415070513 hasAuthorship W2415070513A5082128107 @default.
• W2415070513 hasAuthorship W2415070513A5083380890 @default.
• W2415070513 hasBestOaLocation W24150705131 @default.
• W2415070513 hasConcept C113162765 @default.
• W2415070513 hasConcept C119599485 @default.
• W2415070513 hasConcept C120665830 @default.
• W2415070513 hasConcept C121332964 @default.
• W2415070513 hasConcept C126322002 @default.
• W2415070513 hasConcept C127413603 @default.
• W2415070513 hasConcept C163276114 @default.
• W2415070513 hasConcept C203014093 @default.
• W2415070513 hasConcept C2776185287 @default.
• W2415070513 hasConcept C2777391075 @default.
• W2415070513 hasConcept C2777910003 @default.
• W2415070513 hasConcept C2778082588 @default.
• W2415070513 hasConcept C2778416477 @default.
• W2415070513 hasConcept C2779134260 @default.
• W2415070513 hasConcept C2780062933 @default.
• W2415070513 hasConcept C2780122209 @default.
• W2415070513 hasConcept C29456083 @default.
• W2415070513 hasConcept C2993569511 @default.
• W2415070513 hasConcept C3008058167 @default.
• W2415070513 hasConcept C3013748606 @default.
• W2415070513 hasConcept C524204448 @default.
• W2415070513 hasConcept C61511704 @default.
• W2415070513 hasConcept C71924100 @default.
• W2415070513 hasConcept C761482 @default.
• W2415070513 hasConceptScore W2415070513C113162765 @default.
• W2415070513 hasConceptScore W2415070513C119599485 @default.
• W2415070513 hasConceptScore W2415070513C120665830 @default.
• W2415070513 hasConceptScore W2415070513C121332964 @default.
• W2415070513 hasConceptScore W2415070513C126322002 @default.
• W2415070513 hasConceptScore W2415070513C127413603 @default.
• W2415070513 hasConceptScore W2415070513C163276114 @default.
• W2415070513 hasConceptScore W2415070513C203014093 @default.
• W2415070513 hasConceptScore W2415070513C2776185287 @default.
• W2415070513 hasConceptScore W2415070513C2777391075 @default.
• W2415070513 hasConceptScore W2415070513C2777910003 @default.
• W2415070513 hasConceptScore W2415070513C2778082588 @default.
• W2415070513 hasConceptScore W2415070513C2778416477 @default.
• W2415070513 hasConceptScore W2415070513C2779134260 @default.
• W2415070513 hasConceptScore W2415070513C2780062933 @default.
• W2415070513 hasConceptScore W2415070513C2780122209 @default.
• W2415070513 hasConceptScore W2415070513C29456083 @default.
• W2415070513 hasConceptScore W2415070513C2993569511 @default.
• W2415070513 hasConceptScore W2415070513C3008058167 @default.
• W2415070513 hasConceptScore W2415070513C3013748606 @default.
• W2415070513 hasConceptScore W2415070513C524204448 @default.
• W2415070513 hasConceptScore W2415070513C61511704 @default.
• W2415070513 hasConceptScore W2415070513C71924100 @default.
• W2415070513 hasConceptScore W2415070513C761482 @default.
• W2415070513 hasLocation W24150705131 @default.
• W2415070513 hasOpenAccess W2415070513 @default.
• W2415070513 hasPrimaryLocation W24150705131 @default.
• W2415070513 hasRelatedWork W1464602523 @default.
• W2415070513 hasRelatedWork W1779239985 @default.
• W2415070513 hasRelatedWork W1974345816 @default.
• W2415070513 hasRelatedWork W1984198183 @default.
• W2415070513 hasRelatedWork W1987288751 @default.
• W2415070513 hasRelatedWork W1987442090 @default.
• W2415070513 hasRelatedWork W2049129563 @default.
• W2415070513 hasRelatedWork W2056491344 @default.
• W2415070513 hasRelatedWork W2058952708 @default.
• W2415070513 hasRelatedWork W2073722291 @default.
• W2415070513 hasRelatedWork W2090704538 @default.
• W2415070513 hasRelatedWork W2325346601 @default.
• W2415070513 hasRelatedWork W2326326515 @default.
• W2415070513 hasRelatedWork W2406295810 @default.
• W2415070513 hasRelatedWork W2408360366 @default.
• W2415070513 hasRelatedWork W2414577317 @default.
• W2415070513 hasRelatedWork W2990652490 @default.
• W2415070513 hasRelatedWork W3096570324 @default.
• W2415070513 hasRelatedWork W2042620820 @default.
• W2415070513 hasRelatedWork W2134070074 @default.
• W2415070513 isParatext "false" @default.
• W2415070513 isRetracted "false" @default.
• W2415070513 magId "2415070513" @default.

• next