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• W2415142013 abstract "No AccessJournal of Urology1 Aug 1987Piridoxilate-Induced Calcium Oxalate Calculi: A New Drug-Induced Metabolic Nephrolithiasis Michel Daudon, Rene-Jean Reveillaud, Michel Normand, Claude Petit, and Paul Jungers Michel DaudonMichel Daudon More articles by this author , Rene-Jean ReveillaudRene-Jean Reveillaud More articles by this author , Michel NormandMichel Normand More articles by this author , Claude PetitClaude Petit More articles by this author , and Paul JungersPaul Jungers More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43111-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail During the last 4 years we collected 27 specimens of calcium oxalate nephrolithiasis in patients receiving long-term treatment with piridoxilate, a drug composed of an equimolar combination of glyoxylate and pyridoxine. The mean duration of treatment was 3.6 years (range 4 months to 10 years) and the mean daily dose was 580 mg. piridoxilate, which contained 160 mg. glyoxylate. Calculi often recurred, with an average number of 9.9 per patient, and an open operation, shock wave lithotripsy or percutaneous nephrolithotomy was required in 22 patients (81 per cent). Oxalate excretion was 727 ± 246μmol. per day while on the drug and 382 ± 201μmol. per day after the drug was withdrawn. Whewellite was the major component of calculi in all cases but the stones exhibited a peculiar morphological arrangement, with multiple small indentations and a fine mamillary structure. Freshly voided urine specimens contained unusual crystals, which on infrared spectroscopy were composed of calcium oxalate trihydrate, a variety of crystal never observed previously in human urine. Piridoxilate-induced calcium oxalate nephrolithiasis is a new variety of metabolic drug-induced nephrolithiasis. Our observations suggest that even large doses of pyridoxine may be unable to prevent the excessive production of oxalate from glyoxylate. © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAssimos D (2018) Re: Calcium Tartrate Tetrahydrate, Case Report of a Novel Human Kidney StoneJournal of Urology, VOL. 199, NO. 6, (1392-1392), Online publication date: 1-Jun-2018. Volume 138Issue 2August 1987Page: 258-260 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Michel Daudon More articles by this author Rene-Jean Reveillaud More articles by this author Michel Normand More articles by this author Claude Petit More articles by this author Paul Jungers More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2415142013 title "Piridoxilate-Induced Calcium Oxalate Calculi: A New Drug-Induced Metabolic Nephrolithiasis" @default.
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